Publication Name	World Journal of Cardiology
Manuscript ID	2268
Country	India

Received	2013-02-11 15:54
Peer-Review Started	2013-02-12 09:06
To Make the First Decision	2013-03-22 15:54
Return for Revision	2013-03-29 09:40
Revised	2013-04-24 16:08
Second Decision	2013-05-09 12:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-05-10 10:33
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-23 15:13
Publish the Manuscript Online	2013-05-25 21:15

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Autobiography
Article Title	Mechanical breakdown and thrombolysis in subacute massive pulmonary embolism: A prospective trial
Manuscript Source	Invited Manuscript
All Author List	Bishav Mohan, Shibba Takkar Chhabra, Naved Aslam, Gurpreet Singh Wander, Naresh Kumar Sood, Sumati Verma, Anil Kumar Mehra and Sarit Sharma
Funding Agency and Grant Number
Corresponding Author	Bishav Mohan, Professor, Department of Cardiology, Dayanand Medical College and Hospital, Unit Hero DMC Heart Institute, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. bishav_68@yahoo.co.in
Key Words	Mechanical breakdown; Subacute; Thrombolysis; Thromboembolic; Intra pulmonary; Catheter directed
Core Tip	Patients with massive pulmonary embolism presenting subacutely (> 2 wk) have high mortality and older clots in these patients may be less amenable to thrombolysis with increased likelihood of recurrence and thromboembolic pulmonary hypertension. Eight of 70 patients with massive pulmonary embolism presenting subacutely were subjected to mechanical breakdown and intra lesional thrombolysis with urokinase (4400 IU/kg over 10 min followed by 4400 IU/kg per hour over 24 h). Post procedurally, patients documented significant improvement in hemodynamic parameters with 100% survival at 30 d and 6 mo followup. This modality appears to be a promising alternative to high risk surgical procedures in such patients.
Publish Date	2013-05-25 21:15
Citation	Mohan B, Chhabra ST, Aslam N, Wander GS, Sood NK, Verma S, Mehra AK, Sharma S. Mechanical breakdown and thrombolysis in subacute massive pulmonary embolism: A prospective trial. World J Cardiol 2013; 5(5): 141-147
URL	http://www.wjgnet.com/1949-8462/full/v5/i5/141.htm
DOI	http://dx.doi.org/10.4330/wjc.v5.i5.141

Full Article (PDF)	WJC-5-141.pdf
Manuscript File	2268-Review.doc
Answering Reviewers	2268-Answering reviewers.pdf
Copyright License Agreement	2268-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2268-Language certificate.pdf
Peer-review Report	2268-Peer review.pdf
Scientific Editor Work List	2268-Scientific editor work list.doc