Publication Name	World Journal of Psychiatry
Manuscript ID	22707
Country	Venezuela

Received	2015-09-16 16:39
Peer-Review Started	2015-09-21 15:48
To Make the First Decision	2015-10-27 11:16
Return for Revision	2015-10-30 16:19
Revised	2015-11-20 00:00
Second Decision	2015-12-18 11:33
Accepted by Journal Editor-in-Chief	2015-12-19 06:44
Accepted by Executive Editor-in-Chief	2016-01-04 16:39
Articles in Press	2016-01-04 16:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-03 21:13
Publish the Manuscript Online	2016-03-16 12:23

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Prospective Study
Article Title	Isotretinoin was not associated with depression or anxiety: A twelve-week study
Manuscript Source	Invited Manuscript
All Author List	Bella Suarez, Ana Serrano, Yves Cova and Trino Baptista
Funding Agency and Grant Number
Corresponding Author	Trino Baptista, MD, PhD, Professor, Department of Physiology, Los Andes University Medical School, Tulio Febres Cordero Avenue, Merida 5101, Venezuela. trinbap@yahoo.com
Key Words	Isotretinoin; Short-term; Psychopathology; Depression; Anxiety; Other treatments
Core Tip	Isotretinoin (ITT) is frequently used for acne therapy, particularly in young people, but concerns exist regarding the risk of depression and suicide attempts. We conducted a 12-wk prospective study administering a fixed ITT dose in non-psychiatric acne patients an in a non-ITT control group. We used categorical and continuous scales for the assessment of depression and anxiety. The frequency and severity of psychopathology was similar in both treatment groups, stressing the safety of ITT in typical dermatological patients. However, 13.8% ITT subjects and 8.3% of the non-ITT developed clinically significant anxiety and/or depression. Hence, susceptible subjects exist, who deserve further investigation and assistance.
Publish Date	2016-03-16 12:23
Citation	Suarez B, Serrano A, Cova Y, Baptista T. Isotretinoin was not associated with depression or anxiety: A twelve-week study. World J Psychiatr 2016; 6(1): 136-142
URL	http://www.wjgnet.com/2220-3206/full/v6/i1/136.htm
DOI	http://dx.doi.org/10.5498/wjp.v6.i1.136

Full Article (PDF)	WJP-6-136.pdf
Full Article (Word)	WJP-6-136.doc
Manuscript File	22707-Review.doc
Answering Reviewers	22707-Answering reviewers.pdf
Audio Core Tip	22707-Audio core tip.mp3
Biostatistics Review Certificate	22707-Biostatistics statement.pdf
Clinical Trial Registration Statement	22707-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	22707-Conflict-of-interest statement.pdf
Copyright License Agreement	22707-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	22707-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	22707-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	22707-Language certificate.pdf
Peer-review Report	22707-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22707-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22707-Scientific misconduct check.pdf
Scientific Editor Work List	22707-Scientific editor work list.pdf