Publication Name	World Journal of Gastroenterology
Manuscript ID	22710
Country	China

Received	2015-09-19 14:16
Peer-Review Started	2015-09-20 13:16
To Make the First Decision	2015-10-14 17:59
Return for Revision	2015-10-15 13:59
Revised	2015-10-28 07:57
Second Decision	2015-11-02 16:34
Accepted by Journal Editor-in-Chief	2015-11-05 16:57
Accepted by Company Editor-in-Chief	2015-11-19 13:31
Articles in Press	2015-11-19 13:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-11-30 11:29
Typeset the Manuscript	2016-01-07 10:34
Publish the Manuscript Online	2016-03-02 13:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Development of a novel mouse constipation model
Manuscript Source	Unsolicited Manuscript
All Author List	Chao Liang, Kai-Yue Wang, Zhi Yu and Bin Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Basic Research Program of China(973 Program) 2011CB505206 National Natural Science Foundation of China 81202744 National Natural Science Foundation of China 81373749
Corresponding Author	Bin Xu, PhD, Professor, Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine, No.138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. xuuuux@sina.com
Key Words	Cold water; Mouse model; Constipation; ENS
Core Tip	Establishing stable animal models is very important for studying disease pathogenesis to develop strategies for prevention and treatment. Evidence from previous researches has shown recurrent and chronic cold water irritation to stomach can inhibit gastrointestinal motility. In this study, we concluded that irritation with ice-cold saline to mice is a stable, repeatable method in building mice constipation model.
Publish Date	2016-03-02 13:35
Citation	Liang C, Wang KY, Yu Z, Xu B. Development of a novel mouse constipation model. World J Gastroenterol 2016; 22(9): 2799-2810
URL	http://www.wjgnet.com/1007-9327/full/v22/i9/2799.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i9.2799

Full Article (PDF)	WJG-22-2799.pdf
Full Article (Word)	WJG-22-2799.doc
Manuscript File	22710-Review.doc
Answering Reviewers	22710-Answering reviewers.pdf
Audio Core Tip	22710-Audio core tip.mp3
Biostatistics Review Certificate	22710-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	22710-Conflict-of-interest statement.pdf
Copyright License Agreement	22710-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	22710-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	22710-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	22710-Language certificate.pdf
Peer-review Report	22710-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22710-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22710-Scientific misconduct check.pdf
Scientific Editor Work List	22710-Scientific editor work list.pdf