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Articles Published Processes
3/23/2016 4:26:00 PM | Browse: 1293 | Download: 1937
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Received |
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2015-09-18 17:32 |
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Peer-Review Started |
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2015-09-19 12:47 |
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To Make the First Decision |
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2015-10-14 17:59 |
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Return for Revision |
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2015-10-15 14:02 |
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Revised |
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2015-11-09 06:38 |
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Second Decision |
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2015-12-18 16:05 |
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Accepted by Journal Editor-in-Chief |
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2015-12-21 08:58 |
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Accepted by Executive Editor-in-Chief |
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2015-12-30 17:42 |
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Articles in Press |
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2015-12-30 17:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-10 12:23 |
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Publish the Manuscript Online |
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2016-03-23 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Parham Safaie, Mugilan Poongkunran, Ping-Ping Kuang, Asad Javaid, Carl Jacobs, Rebecca Pohlmann, Imad Nasser and Daryl TY Lau |
| Funding Agency and Grant Number |
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| Corresponding Author |
Daryl TY Lau, MD, Associate Professor, Liver Center, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Suite 4A, Boston, MA 02215, United States. dlau@bidmc.harvard.edu
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| Key Words |
Hepatitis B virus; Chronic hepatitis B; Hepatocellular carcinoma; Hepatitis B core antigen; Hepatitis B surface antigen |
| Core Tip |
This study described the distributions and patterns of intrahepatic hepatitis B core antigen and hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B using a novel, modified classification system. The HBeAg negative patients were found to have intense HBsAg in liver tissues despite their lower serum hepatitis B virus (HBV) DNA levels. For those with hepatocellular carcinoma (HCC), we observed high rate of HBV antigen detection in tumor tissues, but not in adjacent non-tumor livers, especially among those with optimal serum HBV DNA suppression. These data support that HCC can be derived from clonal expansion of infected hepatocytes with high carcinogenic potentials and selective resistance to antiviral agents.
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| Publish Date |
2016-03-23 16:22 |
| Citation |
Safaie P, Poongkunran M, Kuang PP, Javaid A, Jacobs C, Pohlmann R, Nasser I, Lau DT. Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma. World J Gastroenterol 2016; 22(12): 3404-3411 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i12/3404.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i12.3404 |
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