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Articles Published Processes
1/21/2016 1:56:00 PM | Browse: 945 | Download: 1726
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Received |
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2015-09-22 08:32 |
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Peer-Review Started |
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2015-10-03 19:48 |
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To Make the First Decision |
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2015-10-27 10:28 |
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Return for Revision |
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2015-10-28 13:31 |
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Revised |
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2015-10-30 01:49 |
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Second Decision |
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2015-11-23 18:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-04 16:31 |
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Articles in Press |
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2015-12-04 16:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-12 22:26 |
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Publish the Manuscript Online |
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2016-01-21 13:56 |
| ISSN |
1949-8462 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Samantha K Atkins, Alison N Moore and Philippe Sucosky |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Foundation |
CMMI-1148558 |
| National Science Foundation |
CMMI-1550144 |
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| Corresponding Author |
Philippe Sucosky, PhD, FAHA, Department of Mechanical and Materials Engineering, Wright State University, 257 Russ Engineering Center, 3640 Colonel Glenn Highway, Dayton, OH 45435,
United States. philippe.sucosky@wright.edu
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| Key Words |
Bicuspid aortic valve; Fluid shear stress; Aortopathy; Remodeling; Matrix metalloproteinases |
| Core Tip |
The bicuspid aortic valve with left-right cusp fusion (LR-BAV) generates a stress overload on the ascending aorta (AA) convexity, which promotes aortic medial degeneration and aortic dilation. While the wall concavity is generally spared from the disease, the protective role of the local hemodynamics has not been demonstrated. This study aimed at comparing matrix metalloproteinase biology in AA concavity tissue subjected to the local hemodynamic stresses generated by a tricuspid aortic valve (TAV) and a LR-BAV. The results suggest that the fluid stresses in the TAV AA and LR-BAV AA concavity result in similar MMP expressions and activities.
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| Publish Date |
2016-01-21 13:56 |
| Citation |
Atkins SK, Moore AN, Sucosky P. Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity. World J Cardiol 2016; 8(1): 89-97 |
| URL |
http://www.wjgnet.com/1949-8462/full/v8/i1/89.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v8.i1.89 |
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