Publication Name	World Journal of Hepatology
Manuscript ID	22790
Country	China

Received	2015-09-24 08:33
Peer-Review Started	2015-09-26 20:07
First Decision by Editorial Office Director
Return for Revision	2015-10-29 09:02
Revised	2015-11-11 08:50
Publication Fee Transferred
Second Decision by Editor	2015-12-02 13:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-12-11 16:58
Articles in Press	2015-12-11 16:58
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-22 11:16
Publish the Manuscript Online	2015-12-27 14:34

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Review
Article Title	Crosstalk between innate and adaptive immunity in hepatitis B virus infection
Manuscript Source	Invited Manuscript
All Author List	Li Wang, Kai Wang and Zhi-Qiang Zou
Funding Agency and Grant Number	Funding Agency Grant Number Yantai Science and Technology Plan Project 2012116
Corresponding Author	Li Wang, PhD, Infectious Disease Hospital of Yantai, Huanshan Road 62, Zhifu District, Yantai 264001, Shandong Province, China. liliwang2200@163.com
Key Words	Crosstalk; Hepatitis B virus; Innate immune; Adapative immune
Core Tip	Hepatitis B virus (HBV) is poorly sensed by the innate immune system and can escape innate immune recognition at the early stage of infection. HBV-specific T-cell responses are timely and efficiently induced in acute self-limited infections but are deeply exhausted in chronic hepatitis B. The tolerogenic effect of the liver environment and the persistent exposure of T cells to high antigen loads play a key role in the pathogenesis of T-cell inhibition in chronic HBV infection. Combination of reduction of HBV and virus antigen loads and restoration of the anti-viral T-cell function may represent a strategy to cure chronic HBV infections.
Publish Date	2015-12-27 14:34
Citation	Wang L, Wang K, Zou ZQ. Crosstalk between innate and adaptive immunity in hepatitis B virus infection. World J Hepatol 2015; 7(30): 2980-2991
URL	http://www.wjgnet.com/1948-5182/full/v7/i30/2980.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i30.2980

Full Article (PDF)	WJH-7-2980.pdf
Full Article (Word)	WJH-7-2980.doc
Manuscript File	22790-Review.doc
Answering Reviewers	22790-Answering reviewers.pdf
Audio Core Tip	22790-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22790-Conflict-of-interest statement.pdf
Copyright License Agreement	22790-Copyright assignment.pdf
Peer-review Report	22790-Peer-review(s).pdf
Scientific Misconduct Check	22790-Scientific misconduct check.pdf
Scientific Editor Work List	22790-Scientific editor work list.pdf