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Articles Published Processes
9/4/2016 2:49:00 PM | Browse: 951 | Download: 1999
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Received |
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2015-09-27 18:15 |
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Peer-Review Started |
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2015-09-28 16:08 |
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To Make the First Decision |
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2015-11-27 16:48 |
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Return for Revision |
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2015-11-30 09:46 |
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Revised |
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2016-02-05 00:00 |
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Second Decision |
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2016-05-11 15:56 |
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Accepted by Journal Editor-in-Chief |
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2016-05-11 22:12 |
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Accepted by Executive Editor-in-Chief |
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2016-05-23 16:23 |
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Articles in Press |
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2016-05-23 16:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-01 08:39 |
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Publish the Manuscript Online |
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2016-09-04 14:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was
selected by an in-house editor and fully peer-reviewed by external
reviewers. It is distributed in accordance with the Creative
Commons Attribution Non Commercial (CC BY-NC 4.0) license,
which permits others to distribute, remix, adapt, build upon this
work non-commercially, and license their derivative works on
different terms, provided the original work is properly cited and
the use is non-commercial. See: http://creativecommons.org/
licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing
Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Niteen Tapuria, Sameer Junnarkar, Mahmoud Abu-amara, Barry Fuller, Alexander M Seifalian and Brian R Davidson |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Peter Samuel Grant, Royal Free NHS trust United Kingdom |
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| Corresponding Author |
Niteen Tapuria, MS, MD (research), FRCS, FRCS (Gen Surg), Department of HPB Surgery and Liver transplantation, Royal Free Hospital, Hampstead, London NW32QG, United Kingdom. ntapuria@yahoo.com |
| Key Words |
Reperfusion injury; CINC; Microcirculation; Ischemic preconditioning; Remote preconditioning; Haemoxygenase |
| Core Tip |
This study is novel in demonstrating the in vivo microcirculatory changes due to haemoxygenase (HO) induced by Remote ischemic preconditioning by brief hind limb ischemia (RIPC) in hepatic ischemia reperfusion (IR) injury. HO also decreased CINC levels (cytokine secreted from kupffer cells in hepatic IR) which is significant in reducing neutrophil recruitment and IR injury. HO inhibition abolished the protective effect of RIPC on hepatic microcirculation and was associated with significantly elevated CINC levels, serum transaminases and hepatocellular death. These findings are novel and have not been demonstrated in previous studies. RIPC may have a potential role in donor preconditioning.
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| Publish Date |
2016-09-04 14:49 |
| Citation |
Tapuria N, Junnarkar S, Abu-amara M, Fuller B, Seifalian AM, Davidson BR. Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury. World J Gastroenterol 2016; 22(33): 7518-7535 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i33/7518.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i33.7518 |
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