Publication Name	World Journal of Gastroenterology
Manuscript ID	22797
Country	Japan

Received	2015-11-11 08:52
Peer-Review Started	2015-11-11 19:29
To Make the First Decision	2015-12-21 11:42
Return for Revision	2015-12-21 14:00
Revised	2016-01-22 16:05
Second Decision	2016-03-11 09:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-18 17:36
Articles in Press	2016-03-18 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-09-19 22:26
Typeset the Manuscript	2016-10-12 14:44
Publish the Manuscript Online	2016-10-20 17:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Hiroshi Kono, Hideki Fujii, Shinji Furuya, Michio Hara, Kazuyoshi Hirayama, Yoshihiro Akazawa, Yuuki Nakata, Masato Tsuchiya, Naohiro Hosomura and Chao Sun
Funding Agency and Grant Number
Corresponding Author	Hiroshi Kono, MD, PhD, First Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan. hkouno@yamanashi.ac.jp
Key Words	M2 macrophage; Vascular endothelial growth factor; Vascular endothelial cell; Monocyte; Angiogenesis
Core Tip	This study was designed to investigate the role of macrophage colony-stimulating factor (M-CSF) in patients with hepatocellular carcinoma (HCC) after resection. Groups with high density of M-CSF, CD163 or CD31 showed a significantly shorter time to recurrence (TTR) than low density groups. Multivariate analysis revealed the expression of M-CSF or hepatic M2Mφs in the peritumoral area as the most crucial factor responsible for shorter TTR. The expression of M-CSF and hepatic M2Mφs in the peritumoral area had better power for the prediction of overall survival. Thus, M-CSF could be a useful target for therapy against HCC.
Publish Date	2016-10-20 17:06
Citation	Kono H, Fujii H, Furuya S, Hara M, Hirayama K, Akazawa Y, Nakata Y, Tsuchiya M, Hosomura N, Sun C. Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma. World J Gastroenterol 2016; 22(39): 8779-8789
URL	http://www.wjgnet.com/1007-9327/full/v22/i39/8779.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i39.8779

Full Article (PDF)	WJG-22-8779.pdf
Full Article (Word)	WJG-22-8779.doc
Manuscript File	22797-Review.docx
Answering Reviewers	22797-Answering reviewers.pdf
Audio Core Tip	22797-Audio core tip.MP3
Biostatistics Review Certificate	22797-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	22797-Conflict-of-interest statement.pdf
Copyright License Agreement	22797-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	22797-Institutional review board statement.pdf
Peer-review Report	22797-Peer-review(s).pdf
Scientific Misconduct Check	22797-Scientific misconduct check.pdf
Scientific Editor Work List	22797-Scientific editor work list.pdf