| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Human cytomegalovirus-encoded US28 may act as a tumor promoter in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Zhai Cai, Jian-Gang Xu, Yu-Hui Zhou, Ji-Hang Zheng, Ke-Zhi Lin, Shu-Zhi Zheng, Meng-Si Ye, Yun He, Chang-Bao Liu and Zhan-Xiong Xue |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Zhejiang Province of China |
LY15H160059 |
| Zhejiang Provincial Medical and Health Science and Technology Project |
2016KYB192 |
| Wenzhou Municipal Science and Technology Bureau |
Y20140691 |
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| Corresponding Author |
Zhan-Xiong Xue, MD, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou 325000, Zhejiang Province, China. xuezhanxiong2015@sina.com
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| Key Words |
Human cytomegalovirus; US28; Colorectal cancer; Prognosis; Proliferation; Invasion |
| Core Tip |
Human cytomegalovirus (HCMV) is strongly correlated to colorectal cancer (CRC), although it remains unclear whether the virus contributes to CRC pathogenesis. We examined the expression of HCMV-encoded US28 protein in 103 CRC patient samples and 98 corresponding adjacent noncancerous samples using immunohistochemistry; the relationship between US28 expression and clinicopathological features was also analyzed. We found that US28 expression differed significantly between colorectal carcinoma and adjacent noncancerous colorectal tissues and that US28 expression was correlated with histological grade, metastasis, Dukes’ stage, and survival. After successful transfection with the US28 gene, LOVO cells exhibited higher viability, greater chemotherapy resistance, accelerated cell cycle progression, and increased invasion. These findings indicate that US28 expression predicts a poor prognosis and may promote the pathogenesis of CRC. Thus, targeting specific HCMV proteins (e.g., US28) in endogenously infected CRC may constitute a novel antitumor approach.
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| Publish Date |
2016-03-02 13:35 |
| Citation |
Cai ZZ, Xu JG, Zhou YH, Zheng JH, Lin KZ, Zheng SZ, Ye MS, He Y, Liu CB, Xue ZX. Human cytomegalovirus-encoded US28 may act as a tumor promoter in colorectal cancer. World J Gastroenterol 2016; 22(9): 2789-2798 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i9/2789.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i9.2789 |
