Publication Name	World Journal of Hepatology
Manuscript ID	2283
Country	France

Received	2013-02-15 17:08
Peer-Review Started	2013-02-16 14:21
To Make the First Decision	2013-03-18 15:55
Return for Revision	2013-03-25 08:59
Revised	2013-06-10 21:03
Second Decision	2013-08-20 10:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-20 12:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-09-18 08:46
Typeset the Manuscript	2013-10-10 16:30
Publish the Manuscript Online	2014-08-29 07:54

ISSN	1948-5182 (online)
Open Access
Copyright
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Pictures of focal nodular hyperplasia and hepatocellular adenomas
Manuscript Source	Invited Manuscript
All Author List	Christine Sempoux, Charles Balabaud and Paulette Bioulac-Sage
Funding Agency and Grant Number	Funding Agency Grant Number Association pour la Recherche sur le Cancer 3194
Corresponding Author	Dr. Paulette Bioulac-Sage, Inserm U1053, Université Bordeaux Segalen, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France. paulette.bioulac-sage@chu-bordeaux.fr
Key Words	Focal nodular hyperplasia; Hepatocellular adenoma; Inflammatory hepatocellular adenoma; Beta catenin; Hepatocyte nuclear factor 1 alpha
Core Tip	In this paper are illustrated macroscopic and microscopic aspects of focal nodular hyperplasia and hepatocellular adenoma. These illustrations represent typical as well as less usual aspects of these two benign hepatocellular tumors. Microscopic pictures are performed using classical routine stains such as HE, trichrome or cytokeratin 7 or less usual markers proven of great interest to identify focal nodular hyperplasia (FNH) such as glutamine synthase or liver fatty acid briding protein, C reactive protein or b catenin to identify hepatocyte nuclear factor 1 alpha mutated hepatocellular adenoma (HCA), inflammatory HCA, β-catenin mutated HCA respectively. These illustrations combined with brief clinical information should be helpful for pathologists for their practice. Indeed if FNH are rather frequent tumor easy to recognize, there are difficulties when key features are lacking or when features such as steatosis or sinusoidal dilatation, features of HCA, are present. The great message of this paper is the possibility to identify HCA subtypes, a key feature for the coming years to better manage patients.
Publish Date	2014-08-29 07:54
Citation	Sempoux C, Balabaud C, Bioulac-Sage P. Pictures of focal nodular hyperplasia and hepatocellular adenomas. World J Hepatol 2014; 6(8): 580-595
URL	http://www.wjgnet.com/1948-5182/full/v6/i8/580.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i8.580

Full Article (PDF)	WJH-6-580.pdf
Full Article (Word)	WJH-6-580.doc
Manuscript File	2283-Review.doc
Answering Reviewers	2283-Answering reviewers.pdf
Copyright License Agreement	2283-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2283-Language certificate.pdf
Peer-review Report	2283-Peer reviews.pdf
Scientific Editor Work List	2283-Scientific editor work list.doc