Publication Name	World Journal of Diabetes
Manuscript ID	22834
Country	Argentina

Received	2015-09-27 18:11
Peer-Review Started	2015-10-03 20:22
To Make the First Decision	2015-12-04 11:21
Return for Revision	2015-12-07 16:59
Revised	2015-12-24 10:49
Second Decision	2016-01-25 14:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-31 14:40
Articles in Press	2016-01-31 14:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-21 16:13
Publish the Manuscript Online	2016-03-23 21:36

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy?
Manuscript Source	Invited Manuscript
All Author List	Antonio Desmond McCarthy, Ana María Cortizo and Claudia Sedlinsky
Funding Agency and Grant Number	Funding Agency Grant Number MINCyT Argentina PICT-2012-0053
Corresponding Author	Antonio Desmond McCarthy, Professor, Laboratorio de Investigaciones en Osteopatías y Metabolismo Mineral, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 50 y 115, La Plata1900, Argentina. mccarthy@biol.unlp.edu.ar
Key Words	Diabetes mellitus; Osteoporosis; Bone fractures; Metformin; AMP-activated kinase
Core Tip	Patients with long-term type 1 and type 2 diabetes mellitus (DM) can develop skeletal compli-cations. These include osteopenia, osteoporosis and increased incidence of low-stress fractures. In this context, it is important to evaluate whether current anti-diabetic treatments can secondarily affect bone metabolism. Over the past decade, several research groups have investigated the effects of metformin on bone, providing a considerable body of pre-clinical (in vitro, ex vivo and in vivo) as well as clinical evidence for an anabolic action of metformin on bone. This could be particularly relevant when considering treatment options for DM in the context of diabetic osteopathy.
Publish Date	2016-03-23 21:36
Citation	McCarthy AD, Cortizo AM, Sedlinsky C. Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy? World J Diabetes 2016; 7(6): 122-133
URL	http://www.wjgnet.com/1948-9358/full/v7/i6/122.htm
DOI	http://dx.doi.org/10.4239/wjd.v7.i6.122

Full Article (PDF)	WJD-7-122.pdf
Full Article (Word)	WJD-7-122.doc
Manuscript File	22834-Review.docx
Answering Reviewers	22834-Answering reviewers.pdf
Audio Core Tip	22834-Audio core tip.wav
Conflict-of-Interest Disclosure Form	22834-Conflict-of-interest statement.pdf
Copyright License Agreement	22834-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22834-Grant application form(s).pdf
Peer-review Report	22834-Peer-review(s).pdf
Scientific Misconduct Check	22834-Scientific misconduct check.pdf
Scientific Editor Work List	22834-Scientific editor work list.pdf