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Publication Name World Journal of Gastroenterology
Manuscript ID 22853
Country/Territory Italy
2015-09-28 17:22
Peer-Review Started
2015-09-29 17:11
To Make the First Decision
2015-11-27 16:47
Return for Revision
2015-11-30 09:12
2015-12-17 16:42
Second Decision
2015-12-29 07:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-01-11 12:59
Articles in Press
2016-01-11 12:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-02-16 11:49
Publish the Manuscript Online
2016-02-25 19:03
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Simone Polvani, Mirko Tarocchi, Sara Tempesti, Lapo Bencini and Andrea Galli
Funding Agency and Grant Number
Funding Agency Grant Number
Fondo per gli Investimenti della Ricerca di Base RBAP10MY35_002
Corresponding author Andrea Galli, MD, PhD, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, viale Pieraccini 6, 50139 Firenze, Italy. a.galli@dfc.unifi.it
Keywords Insulin; Pancreatic cancer; Adipose tissue; Metformin; Nuclear receptor; Leptin; Adiponectin; Inflammation; Thiazolidinediones
Core Tip Pancreatic cancer has a dismal prognosis with an overall five years survival less than 5%. Obesity and diabetes are risk factors of pancreatic ductal adenocarcinoma (PDAC) increasing the likelihood of its development. Agonists of one specific nuclear receptor transcription factor, the peroxisome proliferator-activated receptor γ (PPARγ), are currently used or evaluated for the treatment of these diseases. PPARγ is a well-known protein implicated in the regulation of metabolism, inflammation, and differentiation; standing at the cross-road of these diseases it may be a key factor linking PDAC to diabetes and obesity, a master regulator whose modulation could be the key for PDAC treatment.
Publish Date 2016-02-25 19:03
Citation Polvani S, Tarocchi M, Tempesti S, Bencini L, Galli A. Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer. World J Gastroenterol 2016; 22(8): 2441-2459
Url http://www.wjgnet.com/1007-9327/full/v22/i8/2441.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i8.2441
Full Article (PDF) WJG-22-2441.pdf
Full Article (Word) WJG-22-2441.doc
Manuscript File 22853-Review.doc
Answering Reviewers 22853-Answering reviewers.pdf
Audio Core Tip 22853-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22853-Conflict-of-interest statement.pdf
Copyright License Agreement 22853-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 22853-Grant Application Form.pdf
Peer-review Report 22853-Peer-review(s).pdf
Scientific Misconduct Check 22853-Scientific misconduct check.pdf
Scientific Editor Work List 22853-Scientific editor work list.pdf