Publication Name	World Journal of Gastroenterology
Manuscript ID	22853
Country	Italy

Received	2015-09-28 17:22
Peer-Review Started	2015-09-29 17:11
To Make the First Decision	2015-11-27 16:47
Return for Revision	2015-11-30 09:12
Revised	2015-12-17 16:42
Second Decision	2015-12-29 07:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-01-11 12:59
Articles in Press	2016-01-11 12:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-16 11:49
Publish the Manuscript Online	2016-02-25 19:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Simone Polvani, Mirko Tarocchi, Sara Tempesti, Lapo Bencini and Andrea Galli
Funding Agency and Grant Number	Funding Agency Grant Number Fondo per gli Investimenti della Ricerca di Base RBAP10MY35_002
Corresponding Author	Andrea Galli, MD, PhD, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, viale Pieraccini 6, 50139 Firenze, Italy. a.galli@dfc.unifi.it
Key Words	Insulin; Pancreatic cancer; Adipose tissue; Metformin; Nuclear receptor; Leptin; Adiponectin; Inflammation; Thiazolidinediones
Core Tip	Pancreatic cancer has a dismal prognosis with an overall five years survival less than 5%. Obesity and diabetes are risk factors of pancreatic ductal adenocarcinoma (PDAC) increasing the likelihood of its development. Agonists of one specific nuclear receptor transcription factor, the peroxisome proliferator-activated receptor γ (PPARγ), are currently used or evaluated for the treatment of these diseases. PPARγ is a well-known protein implicated in the regulation of metabolism, inflammation, and differentiation; standing at the cross-road of these diseases it may be a key factor linking PDAC to diabetes and obesity, a master regulator whose modulation could be the key for PDAC treatment.
Publish Date	2016-02-25 19:03
Citation	Polvani S, Tarocchi M, Tempesti S, Bencini L, Galli A. Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer. World J Gastroenterol 2016; 22(8): 2441-2459
URL	http://www.wjgnet.com/1007-9327/full/v22/i8/2441.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i8.2441

Full Article (PDF)	WJG-22-2441.pdf
Full Article (Word)	WJG-22-2441.doc
Manuscript File	22853-Review.doc
Answering Reviewers	22853-Answering reviewers.pdf
Audio Core Tip	22853-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22853-Conflict-of-interest statement.pdf
Copyright License Agreement	22853-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22853-Grant Application Form.pdf
Peer-review Report	22853-Peer-review(s).pdf
Scientific Misconduct Check	22853-Scientific misconduct check.pdf
Scientific Editor Work List	22853-Scientific editor work list.pdf