BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/15/2016 11:40:00 AM | Browse: 918 | Download: 1715
 |
Received |
|
2015-09-29 09:32 |
|
Peer-Review Started |
|
2015-10-01 23:18 |
|
To Make the First Decision |
|
2015-10-27 11:27 |
|
Return for Revision |
|
2015-11-04 12:04 |
|
Revised |
|
2015-12-03 19:59 |
|
Second Decision |
|
2016-01-08 17:30 |
|
Accepted by Journal Editor-in-Chief |
|
2016-01-08 17:36 |
|
Accepted by Executive Editor-in-Chief |
|
2016-01-19 10:24 |
|
Articles in Press |
|
2016-01-19 10:24 |
 |
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2016-01-30 10:05 |
|
Publish the Manuscript Online |
|
2016-02-15 11:40 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatitis C virus inhibitor synergism suggests multistep interactions between heat-shock protein 90 and hepatitis C virus replication
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Naoko Kubota, Masataka Nomoto, Gi-Wook Hwang, Toshihiko Watanabe, Michinori Kohara, Takaji Wakita, Akira Naganuma and Shusuke Kuge |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Shusuke Kuge, Professor, Department of Microbiology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558,
Japan. skuge@tohoku-pharm.ac.jp
|
| Key Words |
Hepatitis C virus; Inhibition of hepatitis C virus release; Cell culture-derived hepatitis C virus; Heat-shock protein 90 inhibitors; Hepatitis C virus RNA replication |
| Core Tip |
Hepatitis C virus (HCV) is a major causative agent of hepatocellular carcinoma. Several non-structural proteins of HCV physically and functionally interact with heat-shock protein 90 (HSP90). Although HSP90 inhibitors, which inhibit the chaperone function of HSP90, have been shown to inhibit HCV replication by several groups, a recent report using a reporter system for HCV RNA replication (replicon) suggests that the effect is nonspecific. Thus, the inhibitory mechanism of HSP90 inhibitors remains controversial. Here, we address the effect of HSP90 inhibitors on the release of JFH1/cell culture-derived HCV from Huh-7 cells, and suggested that, HSP90 inhibitors may also interfere with an HCV replication step that occurs after the synthesis of viral RNA, such as assembly and release.
|
| Publish Date |
2016-02-15 11:40 |
| Citation |
Kubota N, Nomoto M, Hwang GW, Watanabe T, Kohara M, Wakita T, Naganuma A, Kuge S. Hepatitis C virus inhibitor synergism suggests multistep interactions between heat-shock protein 90 and hepatitis C virus replication. World J Hepatol 2016; 8(5): 282-290 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i5/282.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i5.282 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
