| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Clinical impacts of mesothelin expression in gastrointestinal carcinomas
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Takahiro Einama, Futoshi Kawamata, Hirofumi Kamachi, Hiroshi Nishihara, Shigenori Homma, Fumihiko Matsuzawa, Tatsuzo Mizukami, Yuji Konishi, Munenori Tahara, Toshiya Kamiyama, Okio Hino, Akinobu Taketomi and Satoru Todo |
| Funding Agency and Grant Number |
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| Corresponding Author |
Takahiro Einama, MD, PhD, Department of General Surgery, Hokkaido University Graduate School of Medicine, Kita-Ku, Kita 14, Nishi 7, Sapporo, Hokkaido 060-8638, Japan. titiuehahaue@hotmail.com
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| Key Words |
Mesothelin; Luminal membrane expression; Cytoplasmic expression; Tumor marker; Cancer therapy |
| Core Tip |
Mesothelin is a 40-kDa cell surface glycoprotein expressed on normal mesothelial cells lining the pleura, pericardium, and peritoneum. Moreover, mesothelin has been shown to be overexpressed in several cancer types. Recent studies have suggested that the overexpression of mesothelin increases cell proliferation and migration. Furthermore, the expression of mesothelin was related to an unfavourable patient outcome in several human cancers. The limited meso-thelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy. |
| Publish Date |
2016-05-12 16:59 |
| Citation |
Einama T, Kawamata F, Kamachi H, Nishihara H, Homma S, Matsuzawa F, Mizukami T, Konishi Y, Tahara M, Kamiyama T, Hino O, Taketomi A, Todo S. Clinical impacts of mesothelin expression in gastrointestinal carcinomas. World J Gastrointest Pathophysiol 2016; 7(2): 218-222 |
| URL |
http://www.wjgnet.com/2150-5330/full/v7/i2/218.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v7.i2.218 |
