Publication Name	World Journal of Gastroenterology
Manuscript ID	22867
Country	Denmark

Received	2015-09-29 08:54
Peer-Review Started	2015-09-29 17:33
To Make the First Decision	2015-11-13 09:21
Return for Revision	2015-11-23 10:20
Revised	2015-12-19 16:38
Second Decision	2015-12-29 07:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-11 13:00
Articles in Press	2016-01-11 13:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-22 15:28
Publish the Manuscript Online	2016-03-02 13:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pathology
Manuscript Type	Topic Highlights
Article Title	Key players in pancreatic cancer-stroma interaction: cancer-associated fibroblasts, endothelial and inflammatory cells
Manuscript Source	Invited Manuscript
All Author List	Michael Friberg Bruun Nielsen, Michael Bau Mortensen and Sönke Detlefsen
Funding Agency and Grant Number
Corresponding Author	Sönke Detlefsen, MD, PhD, Clinical Associate Professor, Consultant Pathologist, Department of Pathology, Odense University Hospital, University of Southern Denmark, 5000 Odense, Denmark. sonke.detlefsen@rsyd.dk
Key Words	Pancreatic cancer; Desmoplastic stroma; Cancer-associated fibroblast; Inflammatory cells; Pancreatic stellate cell
Core Tip	Pancreatic cancer (PC), the most aggressive type of common cancers, is characterized by a limited response to chemotherapeutics, which are often directed against the PC cells. One of the histological hallmarks of PC is the extensive desmoplastic stromal reaction that surrounds the PC cells. The PC stroma is not simply a bystander of the neoplastic process but plays an active part in disease progression and metastasis. The PC cells, cancer-associated fibroblasts, inflammatory cells, endothelial cells, and the extra-cellular matrix engage in a complex interplay, the modulation of which could hold potential for the future development of new PC therapies.
Publish Date	2016-03-02 13:35
Citation	Nielsen MFB, Mortensen MB, Detlefsen S. Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells. World J Gastroenterol 2016; 22(9): 2678-2700
URL	http://www.wjgnet.com/1007-9327/full/v22/i9/2678.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i9.2678

Full Article (PDF)	WJG-22-2678.pdf
Full Article (Word)	WJG-22-2678.doc
Manuscript File	22867-Review.docx
Answering Reviewers	22867-Answering reviewers.pdf
Audio Core Tip	22867-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22867-Conflict-of-interest statement.pdf
Copyright License Agreement	22867-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22867-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	22867-Language certificate.pdf
Peer-review Report	22867-Peer-review(s).pdf
Scientific Misconduct Check	22867-Scientific misconduct check.pdf
Scientific Editor Work List	22867-Scientific editor work list.pdf