Publication Name	World Journal of Medical Genetics
Manuscript ID	22870
Country	Spain

Received	2015-10-20 08:20
Peer-Review Started	2015-10-21 09:37
To Make the First Decision	2015-11-24 14:48
Return for Revision	2015-11-27 16:34
Revised	2015-12-15 20:42
Second Decision	2016-01-20 16:35
Accepted by Journal Editor-in-Chief	2016-01-20 17:50
Accepted by Executive Editor-in-Chief	2016-02-17 15:17
Articles in Press	2016-02-17 15:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-19 13:31
Publish the Manuscript Online	2016-02-23 13:59

ISSN	2220-3184 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Gene regulatory networks in atrial fibrillation
Manuscript Source	Invited Manuscript
All Author List	Diego Franco, Estefanía Lozano-Velasco and Amelia Aranega
Funding Agency and Grant Number	Funding Agency Grant Number A CNIC translational grant CNIC2006/08 (to Franco D) University of Jaén on translational biomedicine UJA2013/01 (to Franco D)
Corresponding Author	Dr. Diego Franco, Professor, Cardiovascular Development Group, Department of Experimental Biology B3-362, Faculty of Experimental Sciences, University of Jaén, CU Las Lagunillas s/n, 23071 Jaén, Spain. dfranco@ujaen.es
Key Words	Atrial fibrillation; Genetics; MicroRNAs; Genome-wide association studies; PITX2
Core Tip	Atrial fibrillation (AF) is the most prevalent arrhythmogenic defect in the human population. Genetic factors such as mutations in distinct ion channel encoding genes have been described, yet representing less than 10% of all AF cases. Genome wide association studies have widened the genetic culprits contributing to AF. We provide herein a state-of-the art review on the genetic components underlying AF. Experimental evidences demonstrated that PITX2 plays a pivotal role regulating cellular, molecular and electrophysiological characteristics of the developing and adult heart that, if impaired, predispose to AF, leading to complex regulatory networks with transcriptional and post-transcriptional (microRNA) regulatory mechanisms.
Publish Date	2016-02-23 13:59
Citation	Franco D, Lozano-Velasco E, Aranega A. Gene regulatory networks in atrial fibrillation. World J Med Genet 2016; 6(1): 1-16
URL	http://www.wjgnet.com/2220-3184/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.5496/wjmg.v6.i1.1

Full Article (PDF)	WJMG-6-1.pdf
Full Article (Word)	WJMG-6-1.doc
Manuscript File	22870-Review.docx
Answering Reviewers	22870-Answering reviewers.pdf
Audio Core Tip	22870-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	22870-Conflict-of-interest statement.pdf
Copyright License Agreement	22870-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22870-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	22870-Language certificate.pdf
Peer-review Report	22870-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22870-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22870-Scientific misconduct check.pdf
Scientific Editor Work List	22870-Scientific editor work list.pdf