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2/23/2016 2:00:00 PM | Browse: 508 | Download: 654
Publication Name World Journal of Medical Genetics
Manuscript ID 22870
Country/Territory Spain
2015-10-20 08:20
Peer-Review Started
2015-10-21 09:37
To Make the First Decision
2015-11-24 14:48
Return for Revision
2015-11-27 16:34
2015-12-15 20:42
Second Decision
2016-01-20 16:35
Accepted by Journal Editor-in-Chief
2016-01-20 17:50
Accepted by Company Editor-in-Chief
2016-02-17 15:17
Articles in Press
2016-02-17 15:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-02-19 13:31
Publish the Manuscript Online
2016-02-23 13:59
ISSN 2220-3184 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac and Cardiovascular Systems
Manuscript Type Review
Article Title Gene regulatory networks in atrial fibrillation
Manuscript Source Invited Manuscript
All Author List Diego Franco, Estefanía Lozano-Velasco and Amelia Aranega
Funding Agency and Grant Number
Funding Agency Grant Number
A CNIC translational grant CNIC2006/08 (to Franco D)
University of Jaén on translational biomedicine UJA2013/01 (to Franco D)
Corresponding author Dr. Diego Franco, Professor, Cardiovascular Development Group, Department of Experimental Biology B3-362, Faculty of Experimental Sciences, University of Jaén, CU Las Lagunillas s/n, 23071 Jaén, Spain. dfranco@ujaen.es
Keywords Atrial fibrillation; Genetics; MicroRNAs; Genome-wide association studies; PITX2
Core Tip Atrial fibrillation (AF) is the most prevalent arrhythmogenic defect in the human population. Genetic factors such as mutations in distinct ion channel encoding genes have been described, yet representing less than 10% of all AF cases. Genome wide association studies have widened the genetic culprits contributing to AF. We provide herein a state-of-the art review on the genetic components underlying AF. Experimental evidences demonstrated that PITX2 plays a pivotal role regulating cellular, molecular and electrophysiological characteristics of the developing and adult heart that, if impaired, predispose to AF, leading to complex regulatory networks with transcriptional and post-transcriptional (microRNA) regulatory mechanisms.
Publish Date 2016-02-23 13:59
Citation Franco D, Lozano-Velasco E, Aranega A. Gene regulatory networks in atrial fibrillation. World J Med Genet 2016; 6(1): 1-16
Url http://www.wjgnet.com/2220-3184/full/v6/i1/1.htm
DOI http://dx.doi.org/10.5496/wjmg.v6.i1.1
Full Article (PDF) WJMG-6-1.pdf
Full Article (Word) WJMG-6-1.doc
Manuscript File 22870-Review.docx
Answering Reviewers 22870-Answering reviewers.pdf
Audio Core Tip 22870-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 22870-Conflict-of-interest statement.pdf
Copyright License Agreement 22870-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 22870-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 22870-Language certificate.pdf
Peer-review Report 22870-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 22870-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 22870-Scientific misconduct check.pdf
Scientific Editor Work List 22870-Scientific editor work list.pdf