Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	22875
Country	India

Received	2015-09-29 08:59
Peer-Review Started	2015-10-02 15:23
To Make the First Decision	2015-10-27 11:31
Return for Revision	2015-11-04 16:01
Revised	2016-01-07 14:55
Second Decision	2016-02-16 10:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-09 12:42
Articles in Press	2016-03-09 12:42
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-03-17 09:19
Typeset the Manuscript	2016-05-06 11:45
Publish the Manuscript Online	2016-05-17 12:43

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Therapeutics Advances
Article Title	Targeted therapy of gastrointestinal stromal tumours
Manuscript Source	Invited Manuscript
All Author List	Ashish Jakhetiya, Pankaj Kumar Garg, Gaurav Prakash, Jyoti Sharma, Rambha Pandey and Durgatosh Pandey
Funding Agency and Grant Number
Corresponding Author	Dr. Pankaj Kumar Garg, Associate Professor, Department of Surgery, University College of Medi­cal Sciences and Guru Teg Bahadur Hospital, University of Delhi, Dilshad Garden, Delhi 110095, India. dr.pankajgarg@gmail.com
Key Words	Gastrointestinal tumors; Molecular targeted therapy; Protein kinase inhibitors; Imatinib; Survival
Core Tip	Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumours of the gastrointestinal tract. They are characterized by the presence of a driver kinase-activating mutation in either CD-117 or platelet-derived growth factor receptor α. Development of tyrosine kinase inhibitors has led to a paradigm shift in the management of GISTs. Surgery is the primary modality of treatment in localized non-metastatic GISTs. Adjuvant Imatinib for three years is a preferred option for high-risk patients to lessen disease recurrence. The role of neoadjuvant Imatinib is evolving. Imatinib, Sunitinib, and Regorafinib are recommended as first, second and third-line targeted therapies, respectively, for the management of metastatic GISTs.
Publish Date	2016-05-17 12:43
Citation	Jakhetiya A, Garg PK, Prakash G, Sharma J, Pandey R, Pandey D. Targeted therapy of gastrointestinal stromal tumours. World J Gastrointest Surg 2016; 8(5): 345-352
URL	http://www.wjgnet.com/1948-9366/full/v8/i5/345.htm
DOI	http://dx.doi.org/10.4240/wjgs.v8.i5.345

Full Article (PDF)	WJGS-8-345.pdf
Full Article (Word)	WJGS-8-345.doc
Manuscript File	22875-Review.doc
Answering Reviewers	22875-Answering reviewers.pdf
Audio Core Tip	22875-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22875-Conflict-of-interest statement.pdf
Copyright License Agreement	22875-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22875-Language certificate.pdf
Supplementary Material	Supplementary_Material_20150929084918.pdf
Peer-review Report	22875-Peer-review(s).pdf
Scientific Misconduct Check	22875-Scientific misconduct check.pdf
Scientific Editor Work List	22875-Scientific editor work list.pdf