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Articles Published Processes
5/20/2016 11:48:00 AM | Browse: 1195 | Download: 1443
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Received |
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2015-09-30 08:13 |
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Peer-Review Started |
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2015-10-07 18:35 |
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To Make the First Decision |
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2015-11-24 14:53 |
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Return for Revision |
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2015-11-30 15:40 |
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Revised |
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2016-01-15 17:20 |
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Second Decision |
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2016-02-18 11:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-09 12:43 |
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Articles in Press |
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2016-03-09 12:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-07 18:39 |
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Publish the Manuscript Online |
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2016-05-20 11:49 |
| ISSN |
2220-3176 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Review |
| Article Title |
Systems biology applications to study mechanisms of human immunodeficiency virus latency and reactivation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cory H White, Bastiaan Moesker, Angela Ciuffi and Nadejda Beliakova-Bethell |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health, Martin Delaney Collaboratory of AIDS Researchers for Eradication |
U19 AI 096113 |
| Swiss National Science Foundation |
31003A_146579 |
| University of California, San Diego Fellowships for Graduate Researchers, Frontiers of Innovation Scholars Program |
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| Corresponding Author |
Nadejda Beliakova-Bethell, PhD, Department of Medicine, University of California San Diego, Stein Clinical Research Building, Rm. 303, 9500 Gilman Drive, #0679, La Jolla, CA 92093, United States. nbeliako@ucsd.edu |
| Key Words |
Gene expression; Microarrays; RNA-Seq; Systems biology; Human immunodeficiency virus; Viral latency; Disease eradication; Biomarkers; Molecular mechanisms; Latency reversing agents |
| Core Tip |
Gene expression profiling and systems biology methods are reviewed with respect to their possible application in the field of human immunodeficiency virus (HIV) research. Studies profiling gene expression in latently infected and uninfected cells are summarized to illustrate application of these methods to identification of latency biomarkers and the molecular mechanisms contributing to regulation of HIV expression. Studies that measure changes in host and HIV gene expression upon treatment with latency reversing agents (LRAs) highlight uniting themes driving HIV reactivation and identify novel mechanisms of action of LRAs. The field will further benefit from increased adoption of systems biology methods in future studies. |
| Publish Date |
2016-05-20 11:49 |
| Citation |
White CH, Moesker B, Ciuffi A, Beliakova-Bethell N. Systems biology applications to study mechanisms of human immunodeficiency virus latency and reactivation. World J Clin Infect Dis 2016; 6(2): 6-21 |
| URL |
http://www.wjgnet.com/2220-3176/full/v6/i2/6.htm |
| DOI |
http://dx.doi.org/10.5495/wjcid.v6.i2.6 |
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