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7/6/2016 1:52:00 PM | Browse: 624 | Download: 868
Publication Name World Journal of Diabetes
Manuscript ID 22913
Country/Territory Japan
2015-10-02 13:19
Peer-Review Started
2015-10-09 17:52
To Make the First Decision
2015-11-06 11:11
Return for Revision
2015-11-10 10:35
2015-11-24 17:18
Second Decision
2016-02-17 09:14
Accepted by Journal Editor-in-Chief
2016-02-17 21:59
Accepted by Company Editor-in-Chief
2016-05-27 11:30
Articles in Press
2016-05-27 11:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-06-30 14:00
Publish the Manuscript Online
2016-07-06 13:52
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Review
Article Title Role of bile acids in the regulation of the metabolic pathways
Manuscript Source Invited Manuscript
All Author List Hiroki Taoka, Yoko Yokoyama, Kohkichi Morimoto, Naho Kitamura, Tatsuya Tanigaki, Yoko Takashina, Kazuo Tsubota and Mitsuhiro Watanabe
Funding Agency and Grant Number
Corresponding Author Mitsuhiro Watanabe, PhD, Professor of Graduate School of Media and Governance, Professor of Faculty of Environment and Information Studies, Graduate School of Media and Governance, Department of Environment and Information Studies, Keio University, tau42, 5322 Endo, Fujisawa, Kanagawa 252-0882, Japan. wmitsu@sfc.keio.ac.jp
Key Words Bile acids; TGR5/M-BAR; Farnesoid X receptor; Glucose metabolism; Energy metabolism; Lipid metabolism; Bariatric surgery; Microbiota; Incretin; Bile acid binding resin
Core Tip Bile acids (BAs) are important molecules that participate in various metabolic pathways. BA signaling mechanisms are attractive therapeutic targets of the metabolic syndrome. In this review, we show the mecha-nisms of controlling glucose, lipid and energy metabolism via BA signaling. Furthermore, the authors also describe how those basic scientific studies have been applied to the clinical setting. Particularly, bile acid binding resin (BABR) originally used to treat hypercholesterolemia also stimulates incretin secretion and improves glucose metabolism. In addition to BABR, the clinical application of farnesoid X receptor and TGR5/M-BAR agonists are ongoing for the treatment of metabolic syndrome. The effects of bariatric surgery on glycemic control are also associated with BA metabolism.
Publish Date 2016-07-06 13:52
Citation Taoka H, Yokoyama Y, Morimoto K, Kitamura N, Tanigaki T, Takashina Y, Tsubota K, Watanabe M. Role of bile acids in the regulation of the metabolic pathways. World J Diabetes 2016; 7(13): 260-270
URL http://www.wjgnet.com/1948-9358/full/v7/i13/260.htm
DOI http://dx.doi.org/10.4239/wjd.v7.i13.260
Full Article (PDF) WJD-7-260.pdf
Full Article (Word) WJD-7-260.doc
Manuscript File 22913-Review.docx
Answering Reviewers 22913-Answering reviewers.pdf
Audio Core Tip 22913-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22913-Conflict-of-interest statement.pdf
Copyright License Agreement 22913-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 22913-Language certificate.pdf
Peer-review Report 22913-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 22913-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 22913-Scientific misconduct check.pdf
Scientific Editor Work List 22913-Scientific editor work list.pdf