Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	22923
Country	Germany

Received	2015-10-03 14:02
Peer-Review Started	2015-10-04 13:26
To Make the First Decision	2015-11-13 09:02
Return for Revision	2015-11-17 09:50
Revised	2015-12-01 00:22
Second Decision	2016-02-17 09:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-09 12:59
Articles in Press	2016-03-09 12:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-15 09:58
Publish the Manuscript Online	2016-05-10 08:16

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Topic Highlights
Article Title	MicroRNA in rectal cancer
Manuscript Source	Invited Manuscript
All Author List	Azadeh Azizian, Jens Gruber, B Michael Ghadimi and Jochen Gaedcke
Funding Agency and Grant Number
Corresponding Author	Jochen Gaedcke, MD, Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany. jochen.gaedcke@med.uni-goettingen.de
Key Words	Polymorphism; MicroRNA; Rectal cancer; Response; Chemoradiotherapy; Expression
Core Tip	In rectal cancer, a proper staging of the disease determines the subsequent therapy. Also, prediction of prognosis or therapy response could serve to individualize therapy. MicroRNAs (miRNAs) are highly conserved regulators of gene expression, and seem to be promising candidates for biomarkers. Several miRNAs are part of a specific expression profile in rectal cancer tissue, while others have been correlated to clinical parameters and therapy response. However the comparison of different studies shows only little overlap and even partly oppositional results. Differences between analytical methods and tissue storage types can contribute to that. Further func-tional analyses are needed to fully understand the impact of miRNAs in rectal cancer.
Publish Date	2016-05-10 08:16
Citation	Azizian A, Gruber J, Ghadimi BM, Gaedcke J. MircroRNA in rectal cancer. World J Gastrointest Oncol 2016; 8(5): 416-426
URL	http://www.wjgnet.com/1948-5204/full/v8/i5/416.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i5.416

Full Article (PDF)	WJGO-8-416.pdf
Full Article (Word)	WJGO-8-416.doc
Manuscript File	22923-Review.docx
Answering Reviewers	22923-Answering reviewers.pdf
Audio Core Tip	22923-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22923-Conflict-of-interest statement.pdf
Copyright License Agreement	22923-Copyright assignment.pdf
Peer-review Report	22923-Peer-review(s).pdf
Scientific Misconduct Check	22923-Scientific misconduct check.pdf
Scientific Editor Work List	22923-Scientific editor work list.pdf