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1/25/2016 9:27:00 AM | Browse: 457 | Download: 529
Publication Name World Journal of Critical Care Medicine
Manuscript ID 22925
Country of Manuscript Source Germany
Received
2015-10-04 13:48
Peer-Review Started
2015-10-09 18:19
To Make the First Decision
2015-10-27 11:32
Return for Revision
2015-11-04 17:24
Revised
2015-11-13 20:01
Second Decision
2015-12-23 16:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-01-07 17:28
Articles in Press
2016-01-07 17:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-15 08:28
Publish the Manuscript Online
ISSN 2220-3141(online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Critical Care Medicine
Manuscript Type Review
Article Title Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis
Manuscript Source Invited Manuscript
All Author List Lukas Buendgens, Alexander Koch and Frank Tacke
Funding Agency and Grant Number
Funding Agency Grant Number
German Research Foundation DFG Ta434/5-1
Interdisciplinary Center for Clinical Research (IZKF) Aachen
Corresponding author Frank Tacke, MD, PhD, Department of Medicine Ⅲ, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. frank.tacke@gmx.net
Keywords Proton pump inhibitors; Clostridium difficile; Intensive care unit; Gastrointestinal hemorrhage; Stress; Histamine H2 antagonists; Risk assessment; Pneumonia; Physiological; Sucralfate
Core Tip To prevent gastrointestinal (GI) bleeding due to stress-related mucosal disease, critically ill patients are often routinely treated with proton pump inhibitors (PPI) or histamine 2 receptor antagonists (H2RA) for stress ulcer prophylaxis (SUP) in the intensive care unit (ICU). While major GI bleeding is currently rare in the ICU, SUP has not improved the overall survival of ICU patients in large clinical trials. Moreover, PPI and H2RA pose significant risks including toxicity, drug-drug-interactions and infectious complications (e.g., nosocomial pneumonia or Clostridium difficile-associated diarrhea). Instead of routine SUP, risk-adjusted algorithms may better balance benefits and threats of SUP in the ICU.
Publish Date
Citation Buendgens L, Koch A, Tacke F. Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis. World J Crit Care Med 2016; 5(1): 57-64
Url http://www.wjgnet.com/2220-3141/full/v5/i1/57.htm
DOI http://dx.doi.org/10.5492/wjccm.v5.i1.57
Full Article (PDF) WJCCM-5-57.pdf
Full Article (Word) WJCCM-5-57.doc
Manuscript File 22925-Review.docx
Answering Reviewers 22925-Answering reviewers.pdf
Audio Core Tip 22925-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22925-Conflict-of-interest statement.pdf
Copyright License Agreement 22925-Copyright assignment.pdf
Peer-review Report 22925-Peer-review(s).pdf
Scientific Misconduct Check 22925-Scientific misconduct check.pdf
Scientific Editor Work List 22925-Scientific editor work list.pdf