Publication Name	World Journal of Gastroenterology
Manuscript ID	2293
Country	Italy

Received	2013-02-15 17:25
Peer-Review Started	2013-02-16 15:03
To Make the First Decision	2013-03-25 15:18
Return for Revision	2013-03-29 10:03
Revised	2013-04-02 15:16
Second Decision	2013-04-18 16:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-19 05:58
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-25 17:44
Publish the Manuscript Online	2013-07-06 17:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Adipokines and C-reactive protein in relation to bone mineralization in pediatric nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Lucia Pacifico, Mario Bezzi, Concetta Valentina Lombardo, Sara Romaggioli, Flavia Ferraro, Stefano Bascetta and Claudio Chiesa
Funding Agency and Grant Number	Funding Agency Grant Number A Grant from Sapienza University of Rome, Progetti di Ricerca Universitaria 2010-2011
Corresponding Author	Claudio Chiesa, MD, Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere, 00133 Rome, Italy. claudio.chiesa@ift.cnr.it
Key Words	Bone mineralization; Dual energy X-ray absorptiometry; Adipokines; C-reactive protein; Nonalcoholic fatty liver disease; Children
Core Tip	Understanding the mechanisms underlying the relationship between nonalcoholic fatty liver disease (NAFLD) and low bone mineral density (BMD) is important to prevent poor bone mineralization in obese children. We showed that obese children with NAFLD have decreased BMD compared to obese children without liver involvement independently of adiposity, and that children with more severe histology have worse mineral status than children with more mild abnormalities. We also found a significant independent association of high sensitivity C-reactive protein with BMD scores, supporting the role of an inflammatory state which may accelerate loss of bone mass in patients with NAFLD.
Publish Date	2013-07-06 17:46
Citation	Pacifico L, Bezzi M, Lombardo CV, Romaggioli S, Ferraro F, Bascetta S, Chiesa C. Adipokines and C-reactive protein in relation to bone mineralization in pediatric nonalcoholic fatty liver disease. World J Gastroenterol 2013; 19(25): 4007-4014
URL	http://www.wjgnet.com/1007-9327/full/v19/i25/4007.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i25.4007

Full Article (PDF)	WJG-19-4007.pdf
Manuscript File	2293-Review.doc
Answering Reviewers	2293-Answering reviewers.pdf
Copyright License Agreement	2293-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2293-Language certificate.pdf
Peer-review Report	2293-Peer review.pdf
Scientific Editor Work List	2293-Scientific editor work list.doc