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Articles Published Processes
2/25/2016 7:04:00 PM | Browse: 966 | Download: 1664
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Received |
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2015-10-12 08:33 |
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Peer-Review Started |
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2015-10-12 18:13 |
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To Make the First Decision |
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2015-11-05 11:03 |
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Return for Revision |
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2015-11-06 16:04 |
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Revised |
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2015-11-22 14:29 |
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Second Decision |
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2015-12-04 17:14 |
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Accepted by Journal Editor-in-Chief |
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2015-12-04 22:08 |
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Accepted by Executive Editor-in-Chief |
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2015-12-14 16:18 |
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Articles in Press |
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2015-12-14 16:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-02-16 14:28 |
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Publish the Manuscript Online |
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2016-02-25 19:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dai Shida, Satoru Inoue, Yuki Yoshida, Atsushi Kodaka, Tsutomu Tsuji and Makoto Tsuiji |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant 2010 from Tokyo Metropolis of Japan |
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| Corresponding Author |
Dai Shida, MD, PhD, Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. dshida-tky@umin.ac.jp
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| Key Words |
Sphingosine kinase 1; Lysophosphatidic acid receptor 2; Carcinogenesis; Colorectal cancer; Sphingosine 1-phosphate |
| Core Tip |
This is the first study examining the mRNA expression of SphK1, an oncogenic kinase that produces sphingosine 1-phosphate (S1P), at the mRNA level and its correlation with the expression of lysophosphatidic acid receptor 2 (LPAR2), a major lysophosphatidic acid (LPA) receptor overexpressed in various cancers, in human colorectal cancer. Colorectal cancer tissue in 22 of 27 patients had higher levels of SphK1 mRNA than in normal tissue. A highly significant positive correlation was found between SphK1 and LPAR2 expression (r = 0.784 and P < 0.01). Our findings suggest that S1P and LPA may play important roles in the development of colorectal cancer via the upregulation of SphK1 and LPAR2.
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| Publish Date |
2016-02-25 19:03 |
| Citation |
Shida D, Inoue S, Yoshida Y, Kodaka A, Tsuji T, Tsuiji M. Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer. World J Gastroenterol 2016; 22(8): 2503-2511 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i8/2503.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i8.2503 |
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