Publication Name	World Journal of Gastroenterology
Manuscript ID	22949
Country	Ireland

Received	2015-10-07 12:46
Peer-Review Started	2015-10-08 14:48
To Make the First Decision	2015-11-05 11:04
Return for Revision	2015-11-06 16:59
Revised	2015-11-19 18:23
Second Decision	2015-12-11 07:57
Accepted by Journal Editor-in-Chief	2015-12-11 08:19
Accepted by Executive Editor-in-Chief	2015-12-21 14:08
Articles in Press	2015-12-21 14:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-09 18:08
Publish the Manuscript Online	2016-03-23 16:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung's disease colon
Manuscript Source	Unsolicited Manuscript
All Author List	Anne-Marie O’Donnell, David Coyle and Prem Puri
Funding Agency and Grant Number
Corresponding Author	Prem Puri, MS, FRCS, FRCS (Ed), FACS, FAAP (Hon.), DSc (Hon.), Professor, National Children’s Research Centre, Our Lady’s Children’s Hospital Crumlin, 12 Dublin, Ireland. prem.puri@ucd.ie
Key Words	Platelet-derived growth factor receptor alpha; Hirschsprung’s disease; Gastrointestinal motility; Aganglionosis; Myenteric plexus
Core Tip	Hirschsprung’s disease is a congenital condition characterised by an absence of ganglia in the distal colon. Platelet-derived growth factor receptor-α-positive (PDGFRα+)-cells are a novel cell type recently found to be involved in gastrointestinal neurotransmission and smooth muscle contractility. Our study has revealed a striking decrease in PDGFRα+-cell expression in Hirschsprung’s disease colon compared to normal control colon. These results suggest an exciting new role for PDGFRα+-cells in the pathophysiology of this complex condition.
Publish Date	2016-03-23 16:22
Citation	O’Donnell AM, Coyle D, Puri P. Deficiency of platelet-derived growth factor receptor--positive cells in Hirschsprung’s disease colon. World J Gastroenterol 2016; 22(12): 3335-3340
URL	http://www.wjgnet.com/1007-9327/full/v22/i12/3335.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i12.3335

Full Article (PDF)	WJG-22-3335.pdf
Full Article (Word)	WJG-22-3335.doc
Manuscript File	22949-Review.docx
Answering Reviewers	22949-Answering reviewers.pdf
Audio Core Tip	22949-Audio core tip.mp3
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20151006183813.docx
Conflict-of-Interest Disclosure Form	Conflict-of-Interest_Statement_20151006183927.docx
Copyright License Agreement	22949-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151006183710.docx
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20151006181902.doc
Peer-review Report	22949-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22949-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22949-Scientific misconduct check.pdf
Scientific Editor Work List	22949-Scientific editor work list.pdf