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5/19/2016 2:49:00 PM | Browse: 467 | Download: 695
Publication Name World Journal of Gastroenterology
Manuscript ID 22963
Country/Territory China
2015-10-12 08:44
Peer-Review Started
2015-10-12 13:20
To Make the First Decision
2016-03-07 09:10
Return for Revision
2016-03-07 10:42
2016-03-20 23:12
Second Decision
2016-04-08 17:29
Accepted by Journal Editor-in-Chief
2016-04-08 20:42
Accepted by Company Editor-in-Chief
2016-04-15 14:10
Articles in Press
2016-04-15 14:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-04-26 21:45
Typeset the Manuscript
2016-05-11 11:42
Publish the Manuscript Online
2016-05-19 14:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells
Manuscript Source Unsolicited Manuscript
All Author List Ling Zeng, Hai-Yun Zhou, Na-Na Tang, Wei-Feng Zhang, Gui-Jun He, Bo Hao, Ya-Dong Feng and Hong Zhu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30800511
Corresponding author Hong Zhu, MD, PhD, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guang Zhou Road, Gulou District, Nanjing 210029, Jiangsu Province, China. zhuhong1059@126.com
Keywords Hypoxia-inducible factor-1 alpha; Hypoxia; Glycolysis; Esophageal neoplasms; Cell metabolism
Core Tip Fluorescence analysis, spectrophotometry, real-time PCR, Western blot and siRNA interference technology were used to investigate the influence of phosphatidylinositol-3-kinase protein kinase B-HIF-1α signaling pathway on glycolysis under hypoxia in esophageal carcinoma cells. The results obtained provide experimental evidence for the mechanism of glycolysis enhanced by hypoxia.
Publish Date 2016-05-19 14:49
Citation Zeng L, Zhou HY, Tang NN, Zhang WF, He GJ, Hao B, Feng YD, Zhu H. Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells. World J Gastroenterol 2016; 22(20): 4868-4880
Url http://www.wjgnet.com/1007-9327/full/v22/i20/4868.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i20.4868
Full Article (PDF) WJG-22-4868.pdf
Full Article (Word) WJG-22-4868.doc
Manuscript File 22963-Review.docx
Answering Reviewers 22963-Answering reviewers.pdf
Audio Core Tip 22963-Audio core tip.mp3
Biostatistics Review Certificate 22963-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 22963-Conflict-of-interest statement.pdf
Copyright License Agreement 22963-Copyright assignment.pdf
Data Sharing Statement 22963-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 22963-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 22963-Institutional animal care and use committee statement.docx
Institutional Review Board Approval Form or Document 22963-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 22963-Language certificate.pdf
Peer-review Report 22963-Peer-review(s).pdf
Scientific Editor Work List 22963-Scientific editor work list.pdf