Publication Name	World Journal of Gastroenterology
Manuscript ID	22963
Country	China

Received	2015-10-12 08:44
Peer-Review Started	2015-10-12 13:20
To Make the First Decision	2016-03-07 09:10
Return for Revision	2016-03-07 10:42
Revised	2016-03-20 23:12
Second Decision	2016-04-08 17:29
Accepted by Journal Editor-in-Chief	2016-04-08 20:42
Accepted by Executive Editor-in-Chief	2016-04-15 14:10
Articles in Press	2016-04-15 14:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-04-26 21:45
Typeset the Manuscript	2016-05-11 11:42
Publish the Manuscript Online	2016-05-19 14:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells
Manuscript Source	Unsolicited Manuscript
All Author List	Ling Zeng, Hai-Yun Zhou, Na-Na Tang, Wei-Feng Zhang, Gui-Jun He, Bo Hao, Ya-Dong Feng and Hong Zhu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30800511
Corresponding Author	Hong Zhu, MD, PhD, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guang Zhou Road, Gulou District, Nanjing 210029, Jiangsu Province, China. zhuhong1059@126.com
Key Words	Hypoxia-inducible factor-1 alpha; Hypoxia; Glycolysis; Esophageal neoplasms; Cell metabolism
Core Tip	Fluorescence analysis, spectrophotometry, real-time PCR, Western blot and siRNA interference technology were used to investigate the influence of phosphatidylinositol-3-kinase protein kinase B-HIF-1α signaling pathway on glycolysis under hypoxia in esophageal carcinoma cells. The results obtained provide experimental evidence for the mechanism of glycolysis enhanced by hypoxia.
Publish Date	2016-05-19 14:49
Citation	Zeng L, Zhou HY, Tang NN, Zhang WF, He GJ, Hao B, Feng YD, Zhu H. Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells. World J Gastroenterol 2016; 22(20): 4868-4880
URL	http://www.wjgnet.com/1007-9327/full/v22/i20/4868.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i20.4868

Full Article (PDF)	WJG-22-4868.pdf
Full Article (Word)	WJG-22-4868.doc
Manuscript File	22963-Review.docx
Answering Reviewers	22963-Answering reviewers.pdf
Audio Core Tip	22963-Audio core tip.mp3
Biostatistics Review Certificate	22963-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	22963-Conflict-of-interest statement.pdf
Copyright License Agreement	22963-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22963-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	22963-Institutional animal care and use committee statement.docx
Institutional Review Board Approval Form or Document	22963-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	22963-Language certificate.pdf
Peer-review Report	22963-Peer-review(s).pdf
Scientific Editor Work List	22963-Scientific editor work list.pdf