Publication Name	World Journal of Hepatology
Manuscript ID	23000
Country	Portugal

Received	2015-10-12 08:08
Peer-Review Started	2015-10-14 14:19
To Make the First Decision	2015-11-06 10:39
Return for Revision	2015-11-11 17:11
Revised	2015-12-02 21:02
Second Decision	2015-12-07 09:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-18 17:09
Articles in Press	2015-12-18 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-11 11:14
Publish the Manuscript Online	2016-01-21 09:23

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Cirrhotic cardiomyopathy: Isn’t stress evaluation always required for the diagnosis?
Manuscript Source	Unsolicited Manuscript
All Author List	Mara Barbosa, Joana Guardado, Carla Marinho, Bruno Rosa, Isabel Quelhas, António Lourenço and José Cotter
Funding Agency and Grant Number
Corresponding Author	Mara Barbosa, MD, Gastroenterology Department, Centro Hospitalar do Alto Ave, Rua dos Cutileiros, Creixomil, 4835 Guimarães, Portugal. maraisabelbarbosa@net.sapo.pt
Key Words	Dobutamine stress echocardiography; Cirrhotic cardiomyopathy; Cirrhosis; Corrected QT interval prolongation; Liver impairment
Core Tip	Our study demonstrates that cirrhotic car-diomyopathy (CCM) is a frequent condition that is independent of the severity of liver disease. Further-more, it shows that CCM is currently underdiagnosed, even after a comprehensive evaluation at rest. Conse-quently, a stress test should always be considered in the diagnostic approach to CCM, as it is here. Moreover, an association between corrected QT (QTc) interval prolongation and the presence of gastroesophageal varices was revealed, irrespective of the diagnosis of CCM. As such, the clinical significance of QTc interval prolongation is emphasized and it can be regarded as a marker of severe liver disease.
Publish Date	2016-01-21 09:23
Citation	Barbosa M, Guardado J, Marinho C, Rosa B, Quelhas I, Lourenço A, Cotter J. Cirrhotic cardiomyopathy: Isn’t stress evaluation always required for the diagnosis? World J Hepatol 2016; 8(3): 200-206
URL	http://www.wjgnet.com/1948-5182/full/v8/i3/200.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i3.200

Full Article (PDF)	WJH-8-200.pdf
Full Article (Word)	WJH-8-200.doc
Manuscript File	23000-Review.docx
Answering Reviewers	23000-Answering reviewers.pdf
Audio Core Tip	23000-Audio core tip.mp3
Biostatistics Review Certificate	23000-Biostatistics statement .pdf
Conflict-of-Interest Disclosure Form	23000-Conflict-of-interest statement .pdf
Copyright License Agreement	23000-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151012022128.pdf
Institutional Review Board Approval Form or Document	23000-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23000-Language certificate.pdf
Peer-review Report	23000-Peer-review(s).pdf
Scientific Misconduct Check	23000-Scientific misconduct check.pdf
Scientific Editor Work List	23000-Scientific editor work list.pdf