Publication Name	World Journal of Gastroenterology
Manuscript ID	23078
Country	China

Received	2015-10-27 09:29
Peer-Review Started	2015-10-27 20:52
To Make the First Decision	2015-12-11 10:18
Return for Revision	2015-12-11 16:09
Revised	2015-12-15 11:42
Second Decision	2015-12-18 15:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-30 17:37
Articles in Press	2015-12-30 17:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-02-19 09:43
Typeset the Manuscript	2016-03-11 15:28
Publish the Manuscript Online	2016-03-28 15:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Observational Study
Article Title	Dual-input two-compartment pharmacokinetic model of dynamic contrast-enhanced magnetic resonance imaging in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Jian-Feng Yang, Zhen-Hua Zhao, Yu Zhang, Li Zhao, Li-Ming Yang, Min-Ming Zhang, Bo-Yin Wang, Ting Wang and Bao-Chun Lu
Funding Agency and Grant Number	Funding Agency Grant Number Public Welfare Projects of Science Technology Department of Zhejiang Province 2014C33151 Medical Research Programs of Zhejiang province 2014KYA215 Medical Research Programs of Zhejiang province 2015KYB398 Medical Research Programs of Zhejiang province 2015RCA024 Medical Research Programs of Zhejiang province 2015KYB403 Research Projects of Public Technology Application of Science and Technology of Shaoxing City 2013D10039
Corresponding Author	Min-Ming Zhang, Professor, Chief, Department of Radiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zhangminming@zju.edu.cn
Key Words	Hepatocellular carcinoma; Dynamic contrast-enhanced magnetic resonance imaging; Pharmacokinetics
Core Tip	Dynamic contrast-enhanced magnetic resonance imaging provides a more comprehensive assessment of microvascular parameters in tumors; however, selection of a pharmacokinetic model that takes into account actual physiopathological status is an essential component of evaluating tumor microvascular permeability and perfusion. Here, we confirm that a dual-input two-compartment tracer kinetic model is suitable for evaluating microvascular properties in advanced hepa-tocellular carcinoma.
Publish Date	2016-03-28 15:05
Citation	Yang JF, Zhao ZH, Zhang Y, Zhao L, Yang LM, Zhang MM, Wang BY, Wang T, Lu BC. Dual-input two-compartment pharmacokinetic model of dynamic contrast-enhanced magnetic resonance imaging in hepatocellular carcinoma. World J Gastroenterol 2016; 22(13): 3652-3662
URL	http://www.wjgnet.com/1007-9327/full/v22/i13/3652.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i13.3652

Full Article (PDF)	WJG-22-3652.pdf
Full Article (Word)	WJG-22-3652.doc
Manuscript File	23078-Review.doc
Answering Reviewers	23078-Answering reviewers.pdf
Audio Core Tip	23078-Audio core tip.mp3
Biostatistics Review Certificate	23078-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23078-Conflict-of-interest statement.pdf
Copyright License Agreement	23078-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	23078-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151026204255.pdf
Institutional Review Board Approval Form or Document	23078-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23078-Language certificate.pdf
Peer-review Report	23078-Peer-review(s).pdf
Scientific Misconduct Check	23078-Scientific misconduct check.pdf
Scientific Editor Work List	23078-Scientific editor work list.pdf