Publication Name	World Journal of Gastroenterology
Manuscript ID	23090
Country	China

Received	2015-10-20 08:14
Peer-Review Started	2015-10-20 08:30
First Decision by Editorial Office Director
Return for Revision	2015-11-09 12:02
Revised
Publication Fee Transferred
Second Decision by Editor	2015-11-19 10:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-11-19 10:33
Articles in Press
Edit the Manuscript by Language Editor	2015-12-02 19:16
Typeset the Manuscript	2015-12-11 15:45
Publish the Manuscript Online	2015-12-24 11:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Sphingosine kinase 1 dependent protein kinase C-δ activation plays an important role in acute liver failure in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Chang Lei, Ling-Ling Yang, Wen Li and Pan Luo
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81160065
Corresponding Author	Yan-Chang Lei, Chief Physician, Department of Infectious Diseases, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, Zhejiang Province, China. ycleihust@sina.com
Key Words	Acute liver failure; Protein kinase C-δ; Sphingosine kinase 1; Nuclear factor-κB
Core Tip	In this study, we found protein kinase C (PKC)-δ expression and activation in liver tissue or peripheral blood mononuclear cells of mice with acute liver failure (ALF). Inhibition of PKC-δ activation attenuated ALF in this animal model. Furthermore, sphingosine kinase 1 (SphK1) was required for PKC-δ activation in LPS-stimulated macrophages and the ALF mouse model. Our findings suggest that SphK1 dependent PKC-δ activation plays an important role in ALF, and inhibition of PKC-δ activation might be a potential therapeutic strategy for this disease.
Publish Date	2015-12-24 11:11
Citation	Lei YC, Yang LL, Li W, Luo P. Sphingosine kinase 1 dependent protein kinase C- activation plays an important role in acute liver failure in mice. World J Gastroenterol 2015; 21(48): 13438-13446
URL	http://www.wjgnet.com/1007-9327/full/v21/i48/13438.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i48.13438

Full Article (PDF)	WJG-21-13438.pdf
Full Article (Word)	WJG-21-13438.doc
Manuscript File	23090-Review.doc
Answering Reviewers	23090-Answering reviewers.pdf
Audio Core Tip	23090-Audio core tip.mp3
Biostatistics Review Certificate	23090-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23090-Conflict-of-interest statement.pdf
Copyright License Agreement	23090-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151019201940.doc
Institutional Animal Care and Use Committee Approval Form or Document	23090-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	23090-Institutional review board statement.pdf
Peer-review Report	23090-Peer-review(s).pdf
Scientific Misconduct Check	23090-Scientific misconduct check.pdf
Scientific Editor Work List	23090-Scientific editor work list.pdf