Publication Name	World Journal of Gastroenterology
Manuscript ID	23112
Country	China

Received	2015-10-22 10:45
Peer-Review Started	2015-10-22 20:36
First Decision by Editorial Office Director
Return for Revision	2015-11-16 16:44
Revised	2015-11-25 11:31
Publication Fee Transferred
Second Decision by Editor	2016-01-06 11:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-01-18 10:25
Articles in Press	2016-01-18 10:25
Edit the Manuscript by Language Editor	2016-01-30 10:52
Typeset the Manuscript	2016-03-02 09:11
Publish the Manuscript Online	2016-03-14 08:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-mei Zhao, Yan Wang, Xiao-ying Huang, Min-fang Huang, Rong Xu, Hai-yang Yue, Bu-gao Zhou, Hong-yan Huang, Qi-meng Sun and Duan-yong Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81260595 National Natural Science Foundation of China 81460679 Natural Science Foundation of Jiangxi Province 20122BAB215046 Chinese Scholarship Council and Jiangxi Province as visiting scholar 201408360106 Chinese Scholarship Council and Jiangxi Province as visiting scholar 201408360110 Science and Technology Project of TCM from the Department of Health of Jiangxi Province 2012A017
Corresponding Author	Dr. Duan-Yong Liu, Associate Professor, Jiangxi University of Traditional Chinese Medicine, 819 Xingwan Road, Nanchang 330004, Jiangxi Province, China. liuduanyong@163.com
Key Words	Astragalus polysaccharide; Colitis; Regulatory T cells; Interleukin-17
Core Tip	Regulatory T (Treg) cells are important to maintain intact mucosal barrier, and dysfunction of Treg cells is closely associated with the development and progression of inflammatory bowel disease. Astragalus membranaceus (AM) is a Chinese herb and has been used for years to strengthen immunity and its root extract has been shown to protect rats against hapten-induced colitis. However, as a main active component of AM, it is still unknown whether astragalus polysaccharide (APS) could protect against experimental colitis by regulating Treg cells. In our study, we found that APS effectively ameliorated 2, 4, 6-trinitrobenzene sulfonic acid-induced experimental colitis in rats, probably through restoring the number of Treg cells, and inhibiting IL-17 levels in Peyer’s patches.
Publish Date	2016-03-14 08:44
Citation	Zhao HM, Wang Y, Huang XY, Huang MF, Xu R, Yue HY, Zhou BG, Huang HY, Sun QM, Liu DY. Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches. World J Gastroenterol 2016; 22(11): 3175-3185
URL	http://www.wjgnet.com/1007-9327/full/v22/i11/3175.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i11.3175

Full Article (PDF)	WJG-22-3175.pdf
Full Article (Word)	WJG-22-3175.doc
Manuscript File	23112-Review.docx
Answering Reviewers	23112-Answering reviewers.pdf
Audio Core Tip	23112-Audio core tip.mp3
Biostatistics Review Certificate	23112-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23112-Conflict-of-interest statement.pdf
Copyright License Agreement	23112-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	23112-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	23112-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23112-Language certificate.pdf
Peer-review Report	23112-Peer-review(s).pdf
Scientific Misconduct Check	23112-Scientific misconduct check.pdf
Scientific Editor Work List	23112-Scientific editor work list.pdf