| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-mei Zhao, Yan Wang, Xiao-ying Huang, Min-fang Huang, Rong Xu, Hai-yang Yue, Bu-gao Zhou, Hong-yan Huang, Qi-meng Sun and Duan-yong Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260595 |
| National Natural Science Foundation of China |
81460679 |
| Natural Science Foundation of Jiangxi Province |
20122BAB215046 |
| Chinese Scholarship Council and Jiangxi Province as visiting scholar |
201408360106 |
| Chinese Scholarship Council and Jiangxi Province as visiting scholar |
201408360110 |
| Science and Technology Project of TCM from the Department of Health of Jiangxi Province |
2012A017 |
|
| Corresponding Author |
Dr. Duan-Yong Liu, Associate Professor, Jiangxi University of Traditional Chinese Medicine, 819 Xingwan Road, Nanchang 330004, Jiangxi Province,
China. liuduanyong@163.com |
| Key Words |
Astragalus polysaccharide; Colitis; Regulatory T cells; Interleukin-17 |
| Core Tip |
Regulatory T (Treg) cells are important to maintain intact mucosal barrier, and dysfunction of Treg cells is closely associated with the development and progression of inflammatory bowel disease. Astragalus membranaceus (AM) is a Chinese herb and has been used for years to strengthen immunity and its root extract has been shown to protect rats against hapten-induced colitis. However, as a main active component of AM, it is still unknown whether astragalus polysaccharide (APS) could protect against experimental colitis by regulating Treg cells. In our study, we found that APS effectively ameliorated 2, 4, 6-trinitrobenzene sulfonic acid-induced experimental colitis in rats, probably through restoring the number of Treg cells, and inhibiting IL-17 levels in Peyer’s patches. |
| Publish Date |
2016-03-14 08:44 |
| Citation |
Zhao HM, Wang Y, Huang XY, Huang MF, Xu R, Yue HY, Zhou BG, Huang HY, Sun QM, Liu DY. Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches. World J Gastroenterol 2016; 22(11): 3175-3185 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i11/3175.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i11.3175 |
