Publication Name	World Journal of Clinical Oncology
Manuscript ID	2312
Country	Italy

Received	2013-02-15 17:52
Peer-Review Started	2013-02-16 17:02
To Make the First Decision	2013-03-11 14:54
Return for Revision	2013-03-18 11:49
Revised
Second Decision	2013-04-15 16:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-16 08:08
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-10 09:58
Publish the Manuscript Online	2013-05-20 09:37

ISSN	2218-4333 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas
Manuscript Source	Invited Manuscript
All Author List	Francesco Perri, Giuseppina Della Vittoria Scarpati, Carlo Buonerba, Giuseppe Di Lorenzo, Francesco Longo, Paolo Muto, Concetta Schiavone, Fabio Sandomenico and Francesco Caponigro
Funding Agency and Grant Number
Corresponding Author	Francesco Perri, MD, Head and Neck Medical Oncology Unit, National Tumor Institute of Naples, Via Mariano Semmola 80131 Naples, Italy. francesco.perri80@alice.it
Key Words	Nasopharyngeal carcinoma; Induction chemotherapy; Concurrent chemoradiotherapy; Adjuvant chemotherapy; Locally advanced disease
Core Tip	Clinical data of 40 patients (33 males, 7 females) with locally advanced nasopharyngeal carcinoma (NPC) treated at two participating institutions from March 2006 to March 2012 were reviewed. Patients received either induction chemotherapy followed by concomitant chemo-radiotherapy (CCRT) (22/40 patients) or CCRT alone (18/40). Patients underwent fiberoscopy with biopsy of the primitive tumor, and a computed tomography scan of the head, neck, chest and abdomen with and without contrast. Cisplatin was used both as induction and as concomitant chemotherapy, while 3D conformal radiation therapy was delivered to the nasopharynx and node areas (total dose, 70 Gy). A complete response rate of approximately 95% was achieved both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone. In the sub-group of twenty patients with a follow-up time longer than 36 mo, the 3-year survival and disease free survival rates were 85% and 75%, respectively. These results showed that both CCRT and induction chemotherapy followed by CCRT have excellent activity in locally advanced NPC. The role of adjuvant chemotherapy remains to be defined.
Publish Date	2013-05-20 09:37
Citation	Perri F, Della Vittoria Scarpati G, Buonerba C, Di Lorenzo G, Longo F, Muto P, Schiavone C, Sandomenico F, Caponigro F. Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas. World J Clin Oncol 2013; 4(2): 47-51
URL	http://www.wjgnet.com/2218-4333/full/v4/i2/47.htm
DOI	http://dx.doi.org/10.5306/wjco.v4.i2.47

Full Article (PDF)	WJCO-4-47.pdf
Manuscript File	2312-Review.doc
Answering Reviewers	2312-Answering reviewers.pdf
Copyright License Agreement	2312-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2312-Language certificate.pdf
Peer-review Report	2312-Peer review.pdf
Scientific Editor Work List	2312-Scientific editor work list.doc