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4/25/2016 8:53:00 PM | Browse: 540 | Download: 571
Publication Name World Journal of Nephrology
Manuscript ID 23164
Country/Territory Australia
Received
2015-10-26 16:43
Peer-Review Started
2015-11-03 09:08
To Make the First Decision
2015-11-24 14:54
Return for Revision
2015-11-30 16:03
Revised
Second Decision
2016-02-25 16:58
Accepted by Journal Editor-in-Chief
2016-02-25 20:04
Accepted by Company Editor-in-Chief
2016-03-14 12:04
Articles in Press
2016-03-14 12:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-04-08 18:22
Publish the Manuscript Online
2016-04-25 20:53
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Urology and Nephrology
Manuscript Type Basic Study
Article Title C5b-9 does not mediate tubulointerstitial injury in experimental acute glomerular disease characterized by selective proteinuria
Manuscript Source Invited Manuscript
All Author List Gopala K Rangan
Funding Agency and Grant Number
Funding Agency Grant Number
United States National Institutes of Health DK34198 (to Dr. Couser)
United States National Institutes of Health DK07467 (to Dr. Couser)
Don Jacquot Fellowship (Australian and New Zealand Society of Nephrology Travelling Fellowship)
BJ Amos Travelling Fellowships (Westmead Hospital)
Medical Research Fund of Western Australia
Fremantle Hospital Medical Research Foundation
National Health and Medical Research Council 230500 (to Dr. Rangan)
Corresponding author Gopala K Rangan, MB BS, PhD, FRACP, Westmead Institute for Medical Research Level 5, Centre for Transplant and Renal Research, 176 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia. g.rangan@sydney.edu.au
Keywords Apoptosis; Proliferation; Tubulointerstitial; Proteinuria; C5b-9; Complement; Rats
Core Tip The intra-renal assembly of the complement membrane attack complex (C5b-9) in the tubular lumen may be one of the principal mediators of chronic tubulointerstitial damage in nephrotic glomerular disease. This study shows that in an acute glomerular disease model (protein overload nephropathy) characterized by the rapid onset of highly selective proteinuria, C5b-9 does not mediate early tubulointerstitial injury. This may be due to the low luminal formation of C5b-9 in this model, and suggests that other factors, such as the filtration of albumin, growth factors and/or microtubular protein-cast obstruction, are more important in the pathogenesis of tubulointerstitial injury under these circumstances.
Publish Date 2016-04-25 20:53
Citation Rangan GK. C5b-9 does not mediate tubulointerstitial injury in experimental acute glomerular disease characterized by selective proteinuria. World J Nephrol 2016; 5(3): 288-299
Url http://www.wjgnet.com/2220-6124/full/v5/i3/288.htm
DOI http://dx.doi.org/10.5527/wjn.v5.i3.288
Full Article (PDF) WJN-5-288.pdf
Full Article (Word) WJN-5-288.doc
Manuscript File 23164-Review.doc
Answering Reviewers 23164-Answering reviewers.pdf
Audio Core Tip 23164-Audio core tip.WAV
Biostatistics Review Certificate Biostatistics_Statement_20151026145051.doc
Conflict-of-Interest Disclosure Form 23164-Conflict-of-interest statement.pdf
Copyright License Agreement 23164-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 23164-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 23164-Institutional review board statement.pdf
Peer-review Report 23164-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 23164-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 23164-Scientific misconduct check.pdf
Scientific Editor Work List 23164-Scientific editor work list.pdf