Publication Name	World Journal of Nephrology
Manuscript ID	23164
Country	Australia

Received	2015-10-26 16:43
Peer-Review Started	2015-11-03 09:08
To Make the First Decision	2015-11-24 14:54
Return for Revision	2015-11-30 16:03
Revised
Second Decision	2016-02-25 16:58
Accepted by Journal Editor-in-Chief	2016-02-25 20:04
Accepted by Executive Editor-in-Chief	2016-03-14 12:04
Articles in Press	2016-03-14 12:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-08 18:22
Publish the Manuscript Online	2016-04-25 20:53

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	C5b-9 does not mediate tubulointerstitial injury in experimental acute glomerular disease characterized by selective proteinuria
Manuscript Source	Invited Manuscript
All Author List	Gopala K Rangan
Funding Agency and Grant Number	Funding Agency Grant Number United States National Institutes of Health DK34198 (to Dr. Couser) United States National Institutes of Health DK07467 (to Dr. Couser) Don Jacquot Fellowship (Australian and New Zealand Society of Nephrology Travelling Fellowship) BJ Amos Travelling Fellowships (Westmead Hospital) Medical Research Fund of Western Australia Fremantle Hospital Medical Research Foundation National Health and Medical Research Council 230500 (to Dr. Rangan)
Corresponding Author	Gopala K Rangan, MB BS, PhD, FRACP, Westmead Institute for Medical Research Level 5, Centre for Transplant and Renal Research, 176 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia. g.rangan@sydney.edu.au
Key Words	Apoptosis; Proliferation; Tubulointerstitial; Proteinuria; C5b-9; Complement; Rats
Core Tip	The intra-renal assembly of the complement membrane attack complex (C5b-9) in the tubular lumen may be one of the principal mediators of chronic tubulointerstitial damage in nephrotic glomerular disease. This study shows that in an acute glomerular disease model (protein overload nephropathy) characterized by the rapid onset of highly selective proteinuria, C5b-9 does not mediate early tubulointerstitial injury. This may be due to the low luminal formation of C5b-9 in this model, and suggests that other factors, such as the filtration of albumin, growth factors and/or microtubular protein-cast obstruction, are more important in the pathogenesis of tubulointerstitial injury under these circumstances.
Publish Date	2016-04-25 20:53
Citation	Rangan GK. C5b-9 does not mediate tubulointerstitial injury in experimental acute glomerular disease characterized by selective proteinuria. World J Nephrol 2016; 5(3): 288-299
URL	http://www.wjgnet.com/2220-6124/full/v5/i3/288.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i3.288

Full Article (PDF)	WJN-5-288.pdf
Full Article (Word)	WJN-5-288.doc
Manuscript File	23164-Review.doc
Answering Reviewers	23164-Answering reviewers.pdf
Audio Core Tip	23164-Audio core tip.WAV
Biostatistics Review Certificate	Biostatistics_Statement_20151026145051.doc
Conflict-of-Interest Disclosure Form	23164-Conflict-of-interest statement.pdf
Copyright License Agreement	23164-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	23164-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	23164-Institutional review board statement.pdf
Peer-review Report	23164-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23164-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23164-Scientific misconduct check.pdf
Scientific Editor Work List	23164-Scientific editor work list.pdf