Publication Name	World Journal of Hepatology
Manuscript ID	23196
Country	United Kingdom

Received	2015-10-29 09:03
Peer-Review Started	2015-11-03 16:14
To Make the First Decision	2015-11-24 14:19
Return for Revision	2015-11-30 14:16
Revised	2015-12-22 05:53
Second Decision	2016-01-25 14:48
Accepted by Journal Editor-in-Chief	2016-01-25 16:16
Accepted by Executive Editor-in-Chief	2016-02-16 09:55
Articles in Press	2016-02-16 09:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-17 11:34
Publish the Manuscript Online	2016-03-03 11:05

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion
Manuscript Source	Invited Manuscript
All Author List	Christopher Valerio, Eleni Theocharidou, Andrew Davenport and Banwari Agarwal
Funding Agency and Grant Number
Corresponding Author	Banwari Agarwal, MD, Intensive Care Unit, Royal Free Hospital, Royal Free Hampstead NHS Trust, University College London, Pond Street, London NW3 2QG, United Kingdom. banwari.agarwal@nhs.net
Key Words	Human serum albumin; Human albumin solution; Critical illness; Cirrhosis; Resuscitation fluid; Large-volume paracentesis; Hepatorenal syndrome; Spontaneous bacterial peritonitis
Core Tip	Human serum albumin has several important functions beyond being the principal protein in plasma. In disease states, albumin levels may not only be low but there may also be functional hypoalbuminaemia. This may explain why human albumin solution is helpful in treating the complications of cirrhosis whereas its role (as a volume expander) in critical illness remains limited. However, in the presence of cirrhosis or acute liver failure the restoration of functional albumin may be beneficial, even in critically ill patients. This still needs to be addressed in clinical trials.
Publish Date	2016-03-03 11:05
Citation	Valerio C, Theocharidou E, Davenport A, Agarwal B. Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion. World J Hepatol 2016; 8(7): 345-354
URL	http://www.wjgnet.com/1948-5182/full/v8/i7/345.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i7.345

Full Article (PDF)	WJH-8-345.pdf
Full Article (Word)	WJH-8-345.doc
Manuscript File	23196-Review.docx
Answering Reviewers	23196-Answering reviewers.pdf
Audio Core Tip	23196-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23196-Conflict-of-interest statement.pdf
Copyright License Agreement	23196-Copyright assignment.pdf
Peer-review Report	23196-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23196-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23196-Scientific misconduct check.pdf
Scientific Editor Work List	23196-Scientific editor work list.pdf