Publication Name	World Journal of Gastroenterology
Manuscript ID	23199
Country	China

Received	2015-11-24 08:26
Peer-Review Started	2015-11-25 09:02
To Make the First Decision	2015-12-11 10:17
Return for Revision	2015-12-11 15:57
Revised	2015-12-21 16:16
Second Decision	2015-12-29 07:59
Accepted by Journal Editor-in-Chief	2015-12-29 18:51
Accepted by Executive Editor-in-Chief	2016-01-11 13:01
Articles in Press	2016-01-11 13:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-01-22 22:23
Typeset the Manuscript	2016-02-18 20:23
Publish the Manuscript Online	2016-03-28 15:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Apoptosis of human gastric carcinoma cells induced by Euphorbia esula latex
Manuscript Source	Unsolicited Manuscript
All Author List	Zhao-Ying Fu, Xiao-Dong Han, Ai-Hong Wang and Xiao-Bin Liu
Funding Agency and Grant Number	Funding Agency Grant Number Shaanxi Provincial High-Level University Construction Project in Basic Medical Sciences 2013SXTS02 Yan’an Science and Technology Department 2014HM-05
Corresponding Author	Dr. Zhao-Ying Fu, Professor, Institute of Molecular Biology and Immunology, Yan’an University, Yan’an 716000, Shaanxi Province, China. yadxfzy@yau.edu.cn
Key Words	Euphorbia esula Linn; Apoptosis; Gastric carcinoma; Caspase; Bax; Bcl2
Core Tip	Latex of Euphorbia esula (E. esula) is used to treat benign growths in traditional Chinese medicine. This led us to design an experiment to establish whether latex of E. esula can cause apoptosis. We found that E. esula extract inhibited proliferation and induced apoptosis in SGC-7901 cells, and that the action was caspase dependent and involved upregulation of Bax gene and downregulation of Bcl2 gene.
Publish Date	2016-03-28 15:05
Citation	Fu ZY, Han XD, Wang AH, Liu XB. Apoptosis of human gastric carcinoma cells induced by Euphorbia esula latex. World J Gastroenterol 2016; 22(13): 3564-3572
URL	http://www.wjgnet.com/1007-9327/full/v22/i13/3564.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i13.3564

Full Article (PDF)	WJG-22-3564.pdf
Full Article (Word)	WJG-22-3564.doc
Manuscript File	23199-Review.doc
Answering Reviewers	23199-Answering reviewers.pdf
Audio Core Tip	23199-Audio core tip.mp3
Biostatistics Review Certificate	23199-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23199-Conflict-of-interest statement.pdf
Copyright License Agreement	23199-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	23199-Grant application forms.pdf
Institutional Animal Care and Use Committee Approval Form or Document	23199-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	23199-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23199-Language certificate.pdf
Peer-review Report	23199-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23199-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23199-Scientific misconduct check.pdf
Scientific Editor Work List	23199-Scientific editor work list.pdf