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1/6/2016 4:13:00 PM | Browse: 474 | Download: 445
Publication Name World Journal of Gastroenterology
Manuscript ID 23207
Country/Territory United States
Received
2015-10-30 09:54
Peer-Review Started
2015-10-31 20:04
To Make the First Decision
2015-11-13 09:21
Return for Revision
2015-11-23 10:15
Revised
2015-12-05 06:50
Second Decision
2015-12-11 11:56
Accepted by Journal Editor-in-Chief
2015-12-12 03:57
Accepted by Company Editor-in-Chief
2015-12-21 14:04
Articles in Press
2015-12-21 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-21 17:09
Publish the Manuscript Online
2016-01-06 16:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Review
Article Title Targeting Wnt/ β-catenin pathway in hepatocellular carcinoma treatment
Manuscript Source Invited Manuscript
All Author List Valery Vilchez, Lilia Turcios, Francesc Marti and Roberto Gedaly
Funding Agency and Grant Number
Corresponding author Roberto Gedaly, MD, Department of Surgery, Division of Transplantation, College of Medicine, University of Kentucky, Lexington, KY 40536-0284, United States. rgeda2@uky.edu
Keywords Hepatocellular carcinoma; Wnt/β-catenin pathway; Liver cancer stem cells; Molecular therapy
Core Tip Several signaling pathways have been described to be deregulated in hepatocellular carcinoma (HCC). There are limited treatment options currently available in advanced liver cancer. Wnt/β-catenin pathway is frequently upregulated and has emerged as an alternative target in HCC. Our group has studied the role of β-catenin inhibition alone and in combination in HCC treatment. In this review we summarized the existing literature on the importance of Wnt/β-catenin pathway on hepatocarcinogenesis, tumor progression, relationship with liver stem cells and cancer therapeutics.
Publish Date 2016-01-06 16:13
Citation Vilchez V, Turcios L, Marti F, Gedaly R. Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment. World J Gastroenterol 2016; 22(2): 823-832
Url http://www.wjgnet.com/1007-9327/full/v22/i2/823.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i2.823
Full Article (PDF) WJG-22-823.pdf
Full Article (Word) WJG-22-823.doc
Manuscript File 23207-Review.docx
Answering Reviewers 23207-Answering reviewers.pdf
Audio Core Tip 23207-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 23207-Conflict-of-interest statement.pdf
Copyright License Agreement 23207-Copyright assignment.pdf
Peer-review Report 23207-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 23207-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 23207-Scientific misconduct check.pdf
Scientific Editor Work List 23207-Scientific editor work list.pdf