Publication Name	World Journal of Gastroenterology
Manuscript ID	23207
Country	United States

Received	2015-10-30 09:54
Peer-Review Started	2015-10-31 20:04
To Make the First Decision	2015-11-13 09:21
Return for Revision	2015-11-23 10:15
Revised	2015-12-05 06:50
Second Decision	2015-12-11 11:56
Accepted by Journal Editor-in-Chief	2015-12-12 03:57
Accepted by Executive Editor-in-Chief	2015-12-21 14:04
Articles in Press	2015-12-21 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-21 17:09
Publish the Manuscript Online	2016-01-06 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Review
Article Title	Targeting Wnt/ β-catenin pathway in hepatocellular carcinoma treatment
Manuscript Source	Invited Manuscript
All Author List	Valery Vilchez, Lilia Turcios, Francesc Marti and Roberto Gedaly
Funding Agency and Grant Number
Corresponding Author	Roberto Gedaly, MD, Department of Surgery, Division of Transplantation, College of Medicine, University of Kentucky, Lexington, KY 40536-0284, United States. rgeda2@uky.edu
Key Words	Hepatocellular carcinoma; Wnt/β-catenin pathway; Liver cancer stem cells; Molecular therapy
Core Tip	Several signaling pathways have been described to be deregulated in hepatocellular carcinoma (HCC). There are limited treatment options currently available in advanced liver cancer. Wnt/β-catenin pathway is frequently upregulated and has emerged as an alternative target in HCC. Our group has studied the role of β-catenin inhibition alone and in combination in HCC treatment. In this review we summarized the existing literature on the importance of Wnt/β-catenin pathway on hepatocarcinogenesis, tumor progression, relationship with liver stem cells and cancer therapeutics.
Publish Date	2016-01-06 16:13
Citation	Vilchez V, Turcios L, Marti F, Gedaly R. Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment. World J Gastroenterol 2016; 22(2): 823-832
URL	http://www.wjgnet.com/1007-9327/full/v22/i2/823.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i2.823

Full Article (PDF)	WJG-22-823.pdf
Full Article (Word)	WJG-22-823.doc
Manuscript File	23207-Review.docx
Answering Reviewers	23207-Answering reviewers.pdf
Audio Core Tip	23207-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23207-Conflict-of-interest statement.pdf
Copyright License Agreement	23207-Copyright assignment.pdf
Peer-review Report	23207-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23207-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23207-Scientific misconduct check.pdf
Scientific Editor Work List	23207-Scientific editor work list.pdf