Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	2324
Country	United Kingdom

Received	2013-02-17 08:57
Peer-Review Started	2013-02-17 10:28
To Make the First Decision	2013-03-18 15:54
Return for Revision	2013-03-25 09:31
Revised	2013-03-26 22:05
Second Decision	2013-04-10 16:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-11 05:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-04 14:01
Publish the Manuscript Online	2013-06-13 17:10

ISSN	1948-5204 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	RAS signaling pathways, mutations and their role in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Kypros Zenonos and Katy Kyprianou
Funding Agency and Grant Number
Corresponding Author	Dr. Kypros Zenonos, College of Medical and Dental Sciences, University of Birmingham, Flat 2, 250 High Street, Birmingham B17 9PT, United Kingdom. kxz908@bham.ac.uk
Key Words	Genes; RAS; Colorectal neoplasms; Therapeutics; Mitogen-activated protein kinase signaling system
Core Tip	This review outlines clearly the normal function of the mitogen-activated protein kinases and phosphoinositide-3 kinase cascades, in which the RAS proto-oncogene operates physiologically. It also describes the mutations in these pathways that lead to colorectal cancer (CRC), as well as other mutations outside these cascades affecting RAS function and also leading to CRC. The prognostic value of each mutation is assessed and linked to response rates to available biological treatments. Monoclonal antibodies under development are also briefly discussed.
Publish Date	2013-06-13 17:10
Citation	Zenonos K, Kyprianou K. RAS signaling pathways, mutations and their role in colorectal cancer. World J Gastrointest Oncol 2013; 5(5): 97-101
URL	http://www.wjgnet.com/1948-5204/full/v5/i5/97.htm
DOI	http://dx.doi.org/10.4251/wjgo.v5.i5.97

Full Article (PDF)	WJGO-5-97.pdf
Manuscript File	2324-Review.docx
Answering Reviewers	2324-Answering reviewers.pdf
Copyright License Agreement	2324-Copyright assignment.pdf
Peer-review Report	2324-Peer review.pdf
Scientific Editor Work List	2324-Scientific editor work list.doc