Publication Name	World Journal of Gastroenterology
Manuscript ID	23253
Country	Australia

Received	2015-11-03 08:43
Peer-Review Started	2015-11-04 15:01
To Make the First Decision	2015-11-27 16:31
Return for Revision	2015-12-01 16:00
Revised	2015-12-18 13:07
Second Decision	2015-12-22 16:45
Accepted by Journal Editor-in-Chief	2015-12-23 09:10
Accepted by Executive Editor-in-Chief	2015-12-30 18:01
Articles in Press	2015-12-30 18:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-18 11:49
Publish the Manuscript Online	2016-02-25 19:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state of play
Manuscript Source	Invited Manuscript
All Author List	Bérénice Charrez, Liang Qiao and Lionel Hebbard
Funding Agency and Grant Number	Funding Agency Grant Number National Health and Medical Research Council of Australia 1087297 (Hebbard L) National Health and Medical Research Council of Australia 1047417 (Qiao L) Cancer Council NSW 1070076 (Qiao L) Cancer Council NSW 1069733 (Hebbard L)
Corresponding Author	Dr. Lionel Hebbard, Senior Lecturer, Department of Molecular and Cell Biology, James Cook University, Townsville, QLD 4811, Australia. lionel.hebbard@jcu.edu.au
Key Words	Non-alcoholic steatohepatitis; Hepatocellular carcinoma; Non-alcoholic fatty liver disease; Models; Mice
Core Tip	Non-alcoholic steatohepatitis (NASH) is a metabolic inflammatory disease that can advance to liver cancer. Clinical studies have suggested links between non-alcoholic fatty liver disease, NASH and progression to hepatocellular carcinoma (HCC). Herein, we discuss genomic screens that have illustrated new candidate genes as markers for increased HCC risk. In addition, we present the latest murine models concerning cellular stress and inflammation, which have now been shown to have a role in promoting liver tumor growth.
Publish Date	2016-02-25 19:03
Citation	Charrez B, Qiao L, Hebbard L. Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state of play. World J Gastroenterol 2016; 22(8): 2494-2502
URL	http://www.wjgnet.com/1007-9327/full/v22/i8/2494.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i8.2494

Full Article (PDF)	WJG-22-2494.pdf
Full Article (Word)	WJG-22-2494.doc
Manuscript File	23253-Review.docx
Answering Reviewers	23253-Answering reviewers.pdf
Audio Core Tip	23253-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	23253-Conflict-of-interest statement.pdf
Copyright License Agreement	23253-Copyright assignment.pdf
Peer-review Report	23253-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23253-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23253-Scientific misconduct check.pdf
Scientific Editor Work List	23253-Scientific editor work list.pdf