Publication Name	World Journal of Gastroenterology
Manuscript ID	2330
Country	United Kingdom

Received	2013-02-17 09:24
Peer-Review Started	2013-02-18 09:44
First Decision by Editorial Office Director
Return for Revision	2013-03-18 12:00
Revised
Publication Fee Transferred
Second Decision by Editor	2013-04-10 16:57
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-04-11 05:25
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-24 18:00
Publish the Manuscript Online	2013-07-06 17:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Cytokine profiles in patients receiving antioxidant therapy within the ANTICIPATE trial
Manuscript Source	Invited Manuscript
All Author List	Nehal Shah and Ajith K Siriwardena
Funding Agency and Grant Number	Funding Agency Grant Number An Unrestricted Academic Grant from Pharma Nord, Morpeth, United Kingdom
Corresponding Author	Ajith Siriwardena, MD, FRCS, Professor, Hepato-Pancreato-Biliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom. ajith.siriwardena@cmft.nhs.uk
Key Words	Chronic pancreatitis; Antioxidant therapy; Cytokine
Core Tip	This study examines cytokine levels in a sub-set of patients recruited from within the ANTICIPATE randomized controlled trial of antox for painful chronic pancreatitis. At baseline, pro- and anti-inflammatory cytokine levels were within the laboratory reference range in patients allocated to the antioxidant arm and those allocated to placebo. After 6 mo of intervention with antox, there was a significant elevation in antioxidant levels in patients in the active treatment arm. This was not associated with any change in either pro- or anti-inflammatory cytokine levels. In patients with chronic pancreatitis, with opiate-dependent abdominal pain, circulating cytokine levels are low suggesting that pain in this disease is not simply a manifestation of inflammation.
Publish Date	2013-07-06 17:46
Citation	Shah N, Siriwardena AK. Cytokine profiles in patients receiving antioxidant therapy within the ANTICIPATE trial. World J Gastroenterol 2013; 19(25): 4001-4006
URL	http://www.wjgnet.com/1007-9327/full/v19/i25/4001.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i25.4001

Full Article (PDF)	WJG-19-4001.pdf
Manuscript File	2330-Review.doc
Answering Reviewers	2330-Answering reviewers.pdf
Copyright License Agreement	2330-Copyright assignment.pdf
Peer-review Report	2330-Peer reviews.pdf
Scientific Editor Work List	2330-Scientific editor work list.doc