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Articles Published Processes
3/14/2016 8:44:00 AM | Browse: 888 | Download: 1593
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Received |
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2015-11-08 10:39 |
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Peer-Review Started |
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2015-11-08 10:50 |
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To Make the First Decision |
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2015-11-27 17:27 |
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Return for Revision |
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2015-11-30 09:56 |
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Revised |
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2015-12-14 00:00 |
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Second Decision |
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2015-12-18 15:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-30 17:40 |
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Articles in Press |
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2015-12-30 17:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-01-18 21:41 |
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Typeset the Manuscript |
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2016-02-25 16:13 |
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Publish the Manuscript Online |
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2016-03-14 08:44 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Ling Wang, Jian-Ping Ren, Xue-Qing Wang, Xiao-Hong Wang, Shao-Fang Yang and Yi Xiong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Youth Foundation of Health and Family Planning Commission of Shanxi Province of China |
201301024 |
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| Corresponding Author |
Xiao-Ling Wang, MD, Department of Clinical Laboratory, Shanxi Provincial Hospital of Traditional Chinese Medicine, 46 Bingzhou West Street, Yingze District, Taiyuan 030012, Shanxi Province,
China. wangxiaoling24@163.com |
| Key Words |
Basic core promoter region; Pre-core region; Liver injury; Reverse dot blot hybridization; Mismatch amplification mutation assay |
| Core Tip |
There is no exact evidence about the frequency of mutations in hepatitis B virus (HBV) pre-C and basic core promoter (BCP) regions of HBV in Shanxi Province and the correlation between mutations and disease-related indicators. Here, we found that the frequency of pre-C mutations was higher in hepatitis B e antigen (HBeAg) negative patients, and liver function parameters AST and GGT in the mutation group were higher than those in the wild-type group; however, DNA replication did not increase in the presence of HBV pre-C and BCP mutations. Taken together, HBeAg-negative patients tend to have HBV pre-C mutation. However, these mutations do not cause increased DNA copies, but associate with liver function damage.
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| Publish Date |
2016-03-14 08:44 |
| Citation |
Wang XL, Ren JP, Wang XQ, Wang XH, Yang SF, Xiong Y. Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patients. World J Gastroenterol 2016; 22(11): 3268-3274 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i11/3268.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i11.3268 |
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