Publication Name	World Journal of Gastroenterology
Manuscript ID	2333
Country	China

Received	2013-02-17 09:31
Peer-Review Started	2013-02-18 10:37
To Make the First Decision	2013-03-18 15:53
Return for Revision	2013-03-25 10:08
Revised	2013-04-12 17:12
Second Decision	2013-05-09 12:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-10 10:39
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-27 16:40
Publish the Manuscript Online	2013-06-28 23:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Role of activin A in carbon tetrachloride-induced acute liver injury
Manuscript Source	Invited Manuscript
All Author List	Dong-Hui Wang, Yi-Nan Wang, Jing-Yan Ge, Hai-Yan Liu, Hong-Jun Zhang, Yan Qi, Zhong-Hui Liu and Xue-Ling Cui
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 30801005 Natural Science Foundation of China 81273199 Natural Science Foundation of China 81270513 Project of Science and Development of Jilin Province, China to Liu ZH
Corresponding Author	Dr. Xue-Ling Cui, Department of Genetics, Norman Bethune College of Medicine, Jilin University, 126 Xinmin Street, Changchun 130021, Jilin Province, China. cxl@jlu.edu.cn
Key Words	Liver injury; Carbon tetrachloride; Activin A; Immunohistochemistry
Core Tip	The objective of this study was to investigate the expression and role of activin A in acute liver injury. A carbon tetrachloride (CCl4)-induced acute liver injury mouse model was used. Liver injury effects were examined by measuring alanine aminotransferase and aspartate aminotransferase levels in serum and liver pathological changes. Activin A protein expression levels were detected by enzyme-linked immunosorbent assay and immunohistochemistry. Activin type ⅡA receptor and Smad3 expressions in liver were analyzed by real-time quantitative reverse transcription-polymerase chain reaction. We found that activin A is involved in CCl4-induced acute liver injury, suggesting activin A could be a potential therapeutic option for acute liver injury diseases.
Publish Date	2013-06-28 23:55
Citation	Wang DH, Wang YN, Ge JY, Liu HY, Zhang HJ, Qi Y, Liu ZH, Cui XL. Role of activin A in carbon tetrachloride-induced acute liver injury. World J Gastroenterol 2013; 19(24): 3802-3809
URL	http://www.wjgnet.com/1007-9327/full/v19/i24/3802.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i24.3802

Full Article (PDF)	WJG-19-3802.pdf
Manuscript File	2333-Review.doc
Answering Reviewers	2333-Answering reviewers.pdf
Copyright License Agreement	2333-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2333-Language certificate.pdf
Peer-review Report	2333-Peer reviews.pdf
Scientific Editor Work List	2333-Scientific editor work list.doc