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Articles Published Processes
4/19/2016 9:45:00 AM | Browse: 1431 | Download: 2550
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Received |
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2015-11-10 14:22 |
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Peer-Review Started |
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2015-11-10 16:15 |
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To Make the First Decision |
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2015-12-21 11:42 |
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Return for Revision |
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2015-12-21 13:55 |
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Revised |
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2016-01-13 10:55 |
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Second Decision |
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2016-01-21 11:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-01-30 17:23 |
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Articles in Press |
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2016-01-30 17:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-02-21 12:01 |
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Typeset the Manuscript |
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2016-03-30 11:05 |
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Publish the Manuscript Online |
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2016-04-19 09:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Eukaryotic elongation factor-1α 2 knockdown inhibits hepatocarcinogenesis by suppressing PI3K/Akt/NF-κB signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Nan Qiu, Yi Huang, Dun-Yan Chen, Feng Li, Yan-An Wu, Wen-Bing Wu and Xiao-Li Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Middle-Young Age Backbone Talent Cultivation Program of Fujian Health System |
2013-ZQN-JC-2 |
| Key Projects of Science and Technology Plan of Fujian Province |
2014Y0009 |
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| Corresponding Author |
Yi Huang, PhD, Provincial Clinical College, Fujian Medical University, No. 134 Dong Street, Fuzhou 350001, Fujian Province, China. yihuang8070@sina.com
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| Key Words |
Hepatocellular carcinoma; Carcinogenesis; Eukaryotic elongation factor 1 alpha 2; Proliferation; PI3K/Akt/NF-κB signaling pathway |
| Core Tip |
Whether eukaryotic elongation factor 1 alpha 2 (eEF1A2) affects hepatocellular carcinoma (HCC) biology is largely unknown. In this study, eEF1A2 mRNA and protein levels were significantly higher in HCC cancer tissue samples than in paired control specimens. Efficient eEF1A2 silencing resulted in reduced cell proliferation, migration and invasion, increased apo-ptosis, and induced cell cycle arrest; the PI3K/Akt/NF-κB signaling pathway was notably inhibited. Inversely, eEF1A2 overexpression resulted in promoted cell proliferation, migration and invasion. Our findings indicate that eEF1A2 is a potential oncogene, whose silencing significantly decreases HCC tumorigenesis, likely by inhibiting PI3K/Akt/NF-κB signaling.
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| Publish Date |
2016-04-19 09:42 |
| Citation |
Qiu FN, Huang Y, Chen DY, Li F, Wu YA, Wu WB, Huang XL. Eukaryotic elongation factor-1 2 knockdown inhibits hepatocarcinogenesis by suppressing PI3K/Akt/NF-B signaling. World J Gastroenterol 2016; 22(16): 4226-4237 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i16/4226.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i16.4226 |
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