Publication Name	World Journal of Gastroenterology
Manuscript ID	23342
Country	Italy

Received	2015-11-11 08:47
Peer-Review Started	2015-11-11 18:51
To Make the First Decision	2015-12-11 10:04
Return for Revision	2015-12-14 11:47
Revised	2015-12-22 14:25
Second Decision	2015-12-31 08:03
Accepted by Journal Editor-in-Chief	2015-12-31 15:05
Accepted by Company Editor-in-Chief	2016-01-11 13:08
Articles in Press	2016-01-11 13:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-16 09:12
Publish the Manuscript Online	2016-03-28 15:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Editorial
Article Title	Thermal ablation in colorectal liver metastases: Lack of evidence or lack of capability to prove the evidence?
Manuscript Source	Invited Manuscript
All Author List	Sergio Sartori, Paola Tombesi and Francesca Di Vece
Funding Agency and Grant Number
Corresponding Author	Sergio Sartori, MD, Section of Inter­ventional Ultrasound, St Anna Hospital, via A. Moro 8, 44100 Ferrara, Italy. srs@unife.it
Key Words	Liver metastases; Colorectal cancer; Thermal ablation; Radiofrequency ablation; Microwave ablation; Laser ablation; Systemic chemotherapy
Core Tip	Phase Ⅲ randomized controlled trials (RCT) on the efficacy of thermal ablation combined with systemic chemotherapy in colorectal liver metastases are lacking in literature, and it is very unlikely that ultimate efficacy of ablation treatments will ever be tested again by RCT because of the difficult accrual. However, the best available evidence points toward a benefit for the combination strategy using ablative treatments and chemotherapy.
Publish Date	2016-03-28 15:05
Citation	Sartori S, Tombesi P, Di Vece F. Thermal ablation in colorectal liver metastases: Lack of evidence or lack of capability to prove the evidence? World J Gastroenterol 2016; 22(13): 3511-3515
URL	http://www.wjgnet.com/1007-9327/full/v22/i13/3511.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i13.3511

Full Article (PDF)	WJG-22-3511.pdf
Full Article (Word)	WJG-22-3511.doc
Manuscript File	23342-Review.doc
Answering Reviewers	23342-Answering reviewers.pdf
Audio Core Tip	23342-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23342-Conflict-of-interest statement.pdf
Copyright License Agreement	23342-Copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	23342-Language certificate.pdf
Peer-review Report	23342-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23342-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23342-Scientific misconduct check.pdf
Scientific Editor Work List	23342-Scientific editor work list.pdf