Publication Name	World Journal of Gastroenterology
Manuscript ID	2336
Country	China

Received	2013-02-17 09:35
Peer-Review Started	2013-02-18 11:13
To Make the First Decision	2013-03-11 14:56
Return for Revision	2013-03-18 12:26
Revised
Second Decision	2013-05-09 12:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-10 10:39
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-06-14 16:43
Typeset the Manuscript	2013-06-28 10:56
Publish the Manuscript Online	2013-09-09 09:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Anesthesiology
Manuscript Type	Autobiography
Article Title	Propofol induces apoptosis and increases gemcitabine sensitivity in pancreatic cancer cells in vitro by inhibition of nuclear factor-κB activity
Manuscript Source	Invited Manuscript
All Author List	Qi-Hang Du, Yan-Bing Xu, Meng-Yuan Zhang, Peng Yun and Chang-Yao He
Funding Agency and Grant Number
Corresponding Author	Meng-Yuan Zhang, PhD, Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, Shandong Province, China. duqihang@hotmail.com
Key Words	Pancreatic cancer; Propofol; Gemcitabine; Nuclear factor-κB; Apoptosis
Core Tip	Pretreatment of cells with propofol for 24 h followed by gemcitabine resulted in significant growth inhibition compared with gemcitabine alone. Overall growth inhibition correlated directly with apoptotic cell death. Propofol potentiated gemcitabine-induced killing by downregulation of nuclear factor-κB (NF-κB). In contrast, NF-κB was upregulated when pancreatic cancer cells were exposed to gemcitabine alone. These results suggested that inactivation of the NF-κB signaling pathway by propofol abrogated gemcitabine-induced activation of NF-κB resulting in the chemosensitization of pancreatic tumors to gemcitabine.
Publish Date	2013-09-09 09:30
Citation	Du QH, Xu YB, Zhang MY, Yun P, He CY. Propofol induces apoptosis and increases gemcitabine sensitivity in pancreatic cancer cells in vitro by inhibition of nuclear factor-κB activity. World J Gastroenterol 2013; 19(33): 5485-5492
URL	http://www.wjgnet.com/1007-9327/full/v19/i33/5485.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i33.5485

Full Article (PDF)	WJG-19-5485.pdf
Manuscript File	2336-Review.doc
Answering Reviewers	2336-Answering reviewers.pdf
Copyright License Agreement	2336-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2336-Language certificate.pdf
Peer-review Report	2336-Peer reviews.pdf
Scientific Editor Work List	2336-Scientific editor work list.doc