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Articles Published Processes
4/19/2016 9:45:00 AM | Browse: 983 | Download: 2138
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Received |
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2015-11-26 08:56 |
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Peer-Review Started |
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2015-11-26 16:53 |
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To Make the First Decision |
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2015-12-30 16:39 |
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Return for Revision |
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2015-12-30 17:29 |
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Revised |
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2016-02-01 16:32 |
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Second Decision |
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2016-02-19 09:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-02 08:11 |
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Articles in Press |
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2016-03-02 08:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-08 16:50 |
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Typeset the Manuscript |
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2016-04-01 17:23 |
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Publish the Manuscript Online |
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2016-04-19 09:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dan-Dan Gao, Jia Fu, Bo Qin, Wen-Xiang Huang, Chun Yang and Bei Jia |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Chongqing |
cstc2012jjA10052 |
| Young High-End Medical Reserve Personnel Training Plan Foundation of Chongqing, China |
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| Corresponding Author |
Bei Jia, PhD, Chongqing Key Laboratory of Infectious Diseases and Parasitic Diseases, Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yu Zhong District, Chongqing 400016, China. beijia7410@163.com
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| Key Words |
Acute-on-chronic liver failure; Recombinant adenovirus; Hyper-interleukin-6; Hepatocyte growth factor; Inflammatory cytokines |
| Core Tip |
The purport of our study was to analyse the protective efficacy of recombinant adenovirus containing hyper-interleukin-6 (Hyper-IL-6, HIL-6) and hepatocyte growth factor (HGF) (Ad-HGF-HIL-6) compared to that of recombinant adenovirus HIL-6 or HGF (Ad-HIL-6 or Ad-HGF) in rats with acute-on-chronic liver failure (ACLF). In summary, our results suggest that Ad-HGF-HIL-6 may confer a more powerful protective effect against ACLF than do Ad-HGF or Ad-HIL-6 in rats and can restrain the secretion of diverse inflammatory cytokines and reduce the apoptosis of hepatocytes. Ad-HGF-HIL-6 is likely to be a feasible protective therapy for serious liver injury.
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| Publish Date |
2016-04-19 09:42 |
| Citation |
Gao DD, Fu J, Qin B, Huang WX, Yang C, Jia B. Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats. World J Gastroenterol 2016; 22(16): 4136-4148 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i16/4136.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i16.4136 |
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