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Articles Published Processes
3/23/2016 4:26:00 PM | Browse: 1365 | Download: 2975
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Received |
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2015-11-16 08:29 |
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Peer-Review Started |
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2015-11-16 08:46 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-12-14 11:42 |
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Revised |
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2016-01-08 13:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-01-21 11:27 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2016-01-30 17:25 |
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Articles in Press |
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2016-01-30 17:25 |
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Edit the Manuscript by Language Editor |
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2016-02-17 10:29 |
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Typeset the Manuscript |
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2016-03-08 15:16 |
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Publish the Manuscript Online |
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2016-03-23 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medical Informatics |
| Manuscript Type |
Basic Study |
| Article Title |
Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui Peng, Guang-Xi Zhao, Jing Li, Yu Zhang, Xi-Zhong Shen, Ji-Yao Wang and Jian-Yong Sun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Commission of Shanghai of China |
13ZR1406700 |
| Science and Technology Commission of Shanghai of China |
13DZ1930908 |
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| Corresponding Author |
Jian-Yong Sun, PhD, Department of Gastroenterology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032,
China. sun_jianyong1986@163.com
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| Key Words |
Hepatocellular carcinoma; Nude mice; Auphen; Dibutyryl cAMP; Aquaporin 3; Xenograft tumor model; Aquaporin 9 |
| Core Tip |
This is the first study intending to evaluate the antioncogenic effects of Auphen and dibutyryl cAMP (dbcAMP) in vivo and investigate whether their underlying mechanism involves regulating aquaporin 3 (AQP3) and AQP9 expression. An in-depth description of AQP3 and AQP9 regulation by Auphen and dbcAMP will provide a better understanding of the mechanisms of hepatocarcinogenesis, which could be used in the development of novel therapeutic drugs. This work further confirms the significance of AQP-driven hepatocarcinogenesis, emphasizing the importance of both basic and clinical knowledge of the roles of aquaporins in hepatocellular carcinoma.
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| Publish Date |
2016-03-23 16:22 |
| Citation |
Peng R, Zhao GX, Li J, Zhang Y, Shen XZ, Wang JY, Sun JY. Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo. World J Gastroenterol 2016; 22(12): 3341-3354
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| URL |
http://www.wjgnet.com/1007-9327/full/v22/i12/3341.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i12.3341 |
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