Publication Name	World Journal of Meta-Analysis
Manuscript ID	23482
Country	United Kingdom

Received	2015-11-24 09:14
Peer-Review Started	2015-11-25 19:51
To Make the First Decision	2015-12-28 12:11
Return for Revision	2015-12-28 16:05
Revised	2016-01-19 00:00
Second Decision	2016-02-25 17:00
Accepted by Journal Editor-in-Chief	2016-02-25 22:34
Accepted by Executive Editor-in-Chief	2016-03-14 12:08
Articles in Press	2016-03-14 12:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-01 10:28
Publish the Manuscript Online	2016-04-13 13:54

ISSN	2308-3840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Allergy
Manuscript Type	Systematic Reviews
Article Title	Environmental tobacco smoke exposure and lung cancer: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Peter N Lee, John S Fry, Barbara A Forey, Jan S Hamling and Alison J Thornton
Funding Agency and Grant Number
Corresponding Author	Peter N Lee, MA, Director, P.N. Lee Statistics and Computing Ltd., 17 Cedar Road, Sutton, Surrey SM2 5DA, United Kingdom. peterlee@pnlee.co.uk
Key Words	Passive smoking; Lung neoplasms; Dose-response; Meta-analysis; Review; Confounding factors (epidemiology); Misclassification
Core Tip	We present an up-to-date meta-analysis of the evidence relating non-smoker lung cancer to environmental tobacco smoke (ETS) exposure. We demonstrate a clear risk increase for spousal, at-home, workplace and total exposure, but not childhood exposure. For husband smoking, the relative risk (RR) is estimated as (RR = 1.22, 95%CI: 1.14-1.31). However, adjustment for confounding by education and dietary variables, and correction for misclassified wife’s smoking reduces it to (RR = 1.08, 95%CI: 0.999-1.16). Given the other data limitations and biases we discuss, one cannot reliably conclude that any true ETS effect on lung cancer risk exists. Our results suggest caution in drawing inferences from weak epidemiological associations where known biases exist.
Publish Date	2016-04-13 13:54
Citation	Lee PN, Fry JS, Forey BA, Hamling JS, Thornton AJ. Environ¬mental tobacco smoke exposure and lung cancer: A systematic review. World J Meta-Anal 2016; 4(2): 10-43
URL	http://www.wjgnet.com/2308-3840/full/v4/i2/10.htm
DOI	http://dx.doi.org/10.13105/wjma.v4.i2.10

Full Article (PDF)	WJMA-4-10.pdf
Full Article (Word)	WJMA-4-10.doc
Manuscript File	23482-Review.docx
Answering Reviewers	23482-Answering reviewers.pdf
Audio Core Tip	23482-Audio core tip.mp3
Biostatistics Review Certificate	23482-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23482-Conflict-of-interest statement.pdf
Copyright License Agreement	23482-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20151124090207.docx
Peer-review Report	23482-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23482-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23482-Scientific misconduct check.pdf
Scientific Editor Work List	23482-Scientific editor work list.pdf