Publication Name	World Journal of Gastroenterology
Manuscript ID	23493
Country	Ireland

Received	2015-12-01 09:17
Peer-Review Started	2015-12-01 17:11
To Make the First Decision	2015-12-31 08:49
Return for Revision	2015-12-31 10:46
Revised	2016-01-11 07:49
Second Decision	2016-01-12 16:29
Accepted by Journal Editor-in-Chief	2016-01-12 17:07
Accepted by Company Editor-in-Chief	2016-01-18 11:14
Articles in Press	2016-01-18 11:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-28 10:55
Publish the Manuscript Online	2016-05-17 10:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Basic Study
Article Title	Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung’s-associated enterocolitis
Manuscript Source	Unsolicited Manuscript
All Author List	David Coyle, Justin M Murphy, Brian Doyle, Anne Marie O’Donnell, John Gillick and Prem Puri
Funding Agency and Grant Number
Corresponding Author	Prem Puri, Professor, MS, FRCS, FRCS (Ed), FACS, FAAP (Hon.), DSc (Hon.), National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin Rd., 12 Dublin, Ireland. prem.puri@ucd.ie
Key Words	Serotonin; Tryptophan hydroxylase 2; Hirschsprung; Enterocolitis; Ganglionic
Core Tip	Despite optimal surgery, children with a history of Hirschsprung’s disease (HSCR) complicated by Hirschsprung’s-associated enterocolitis (HAEC) are at higher risk of long-term colonic dysfunction. Tryptophan hydroxylase-2 (TPH2) is a surrogate marker for neuronal 5-hydroxytryptamine (5-HT). We hypothesized that expression of TPH2 is altered in the colon of children with HAEC. We found the density of serotonergic nerves to be differentially reduced in the ganglionic colon of children with HSCR and HAEC compared to those without HAEC compared to controls, although expression is normalized in those with diverting colostomy. Abnormal neuronal 5-HT expression may contribute to post-operative colonic dysfunction in HSCR.
Publish Date	2016-05-17 10:45
Citation	Coyle D, Murphy JM, Doyle B, O’Donnell AM, Gillick J, Puri P. Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung’s-associated enterocolitis. World J Gastroenterol 2016; 22(19): 4662-4672
URL	http://www.wjgnet.com/1007-9327/full/v22/i19/4662.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i19.4662

Full Article (PDF)	WJG-22-4662.pdf
Full Article (Word)	WJG-22-4662.doc
Manuscript File	23493-Review.doc
Answering Reviewers	23493-Answering reviewers.pdf
Audio Core Tip	23493-Audio core tip.mp3
Biostatistics Review Certificate	23493-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23493-Conflict-of-interest statement.pdf
Copyright License Agreement	23493-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151125032806.pdf
Institutional Review Board Approval Form or Document	23493-Institutional review board statement.pdf
Peer-review Report	23493-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23493-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23493-Scientific misconduct check.pdf
Scientific Editor Work List	23493-Scientific editor work list.pdf