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5/19/2016 9:54:00 AM | Browse: 499 | Download: 591
Publication Name World Journal of Gastroenterology
Manuscript ID 23493
Country/Territory Ireland
Received
2015-12-01 09:17
Peer-Review Started
2015-12-01 17:11
To Make the First Decision
2015-12-31 08:49
Return for Revision
2015-12-31 10:46
Revised
2016-01-11 07:49
Second Decision
2016-01-12 16:29
Accepted by Journal Editor-in-Chief
2016-01-12 17:07
Accepted by Company Editor-in-Chief
2016-01-18 11:14
Articles in Press
2016-01-18 11:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-04-28 10:55
Publish the Manuscript Online
2016-05-17 10:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Basic Study
Article Title Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung’s-associated enterocolitis
Manuscript Source Unsolicited Manuscript
All Author List David Coyle, Justin M Murphy, Brian Doyle, Anne Marie O’Donnell, John Gillick and Prem Puri
Funding Agency and Grant Number
Corresponding Author Prem Puri, Professor, MS, FRCS, FRCS (Ed), FACS, FAAP (Hon.), DSc (Hon.), National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin Rd., 12 Dublin, Ireland. prem.puri@ucd.ie
Key Words Serotonin; Tryptophan hydroxylase 2; Hirschsprung; Enterocolitis; Ganglionic
Core Tip Despite optimal surgery, children with a history of Hirschsprung’s disease (HSCR) complicated by Hirschsprung’s-associated enterocolitis (HAEC) are at higher risk of long-term colonic dysfunction. Tryptophan hydroxylase-2 (TPH2) is a surrogate marker for neuronal 5-hydroxytryptamine (5-HT). We hypothesized that expression of TPH2 is altered in the colon of children with HAEC. We found the density of serotonergic nerves to be differentially reduced in the ganglionic colon of children with HSCR and HAEC compared to those without HAEC compared to controls, although expression is normalized in those with diverting colostomy. Abnormal neuronal 5-HT expression may contribute to post-operative colonic dysfunction in HSCR.
Publish Date 2016-05-17 10:45
Citation Coyle D, Murphy JM, Doyle B, O’Donnell AM, Gillick J, Puri P. Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung’s-associated enterocolitis. World J Gastroenterol 2016; 22(19): 4662-4672
Url http://www.wjgnet.com/1007-9327/full/v22/i19/4662.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i19.4662
Full Article (PDF) WJG-22-4662.pdf
Full Article (Word) WJG-22-4662.doc
Manuscript File 23493-Review.doc
Answering Reviewers 23493-Answering reviewers.pdf
Audio Core Tip 23493-Audio core tip.mp3
Biostatistics Review Certificate 23493-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 23493-Conflict-of-interest statement.pdf
Copyright License Agreement 23493-Copyright assignment.pdf
Data Sharing Statement 23493-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20151125032806.pdf
Institutional Review Board Approval Form or Document 23493-Institutional review board statement.pdf
Peer-review Report 23493-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 23493-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 23493-Scientific misconduct check.pdf
Scientific Editor Work List 23493-Scientific editor work list.pdf