Publication Name	World Journal of Gastroenterology
Manuscript ID	23511
Country	United Kingdom

Received	2015-12-03 08:35
Peer-Review Started	2015-12-04 09:18
To Make the First Decision	2016-01-28 15:05
Return for Revision	2016-01-29 13:52
Revised	2016-02-19 04:56
Second Decision	2016-02-24 17:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-03-02 10:29
Articles in Press	2016-03-02 10:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-03-22 06:51
Typeset the Manuscript	2016-04-01 10:28
Publish the Manuscript Online	2016-04-19 09:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study
Manuscript Source	Invited Manuscript
All Author List	I Jane Cox, Abil E Aliev, Mary ME Crossey, Mahvish Dawood, Mamun Al-Mahtab, Sheikh M Akbar, Salimur Rahman, Antonio Riva, Roger Williams and Simon D Taylor-Robinson
Funding Agency and Grant Number
Corresponding Author	I Jane Cox, PhD, Institute of Hepatology, London, Foundation for Liver Research, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom. j.cox@researchinliver.org.uk
Key Words	Urinary metabolic profiling; Hepatocellular carcinoma; Nuclear magnetic resonance spectroscopy; Hepatitis B; Bangladesh
Core Tip	Previous urinary metabolic profiling studies using nuclear magnetic resonance (NMR) spectroscopy of hepatocellular carcinoma (HCC) from Egypt and West Africa suggested the reproducibility of an identifying urinary metabolic profile in HCC. Here, a Bangladeshi HCC cohort was studied to identify similar changes. Urine samples from 142 subjects with hepatitis B HCC, cirrhosis, chronic hepatitis B, or no history of liver disease were analyzed using NMR. Urinary NMR from HCC differed across a range of metabolites, including reduced hippurate and creatinine and increased carnitine levels, consistent with the diverse effects of liver cancer on metabolic pathways and the interrelationship with the gut microbiome. Previous findings were corroborated, suggesting that a panel of metabolic markers could form the basis of a cost-effective HCC dipstick screening test.
Publish Date	2016-04-19 09:42
Citation	Cox IJ, Aliev AE, Crossey MME, Dawood M, Al-Mahtab M, Akbar SM, Rahman S, Riva A, Williams R, Taylor-Robinson SD. Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study. World J Gastroenterol 2016; 22(16): 4191-4200
URL	http://www.wjgnet.com/1007-9327/full/v22/i16/4191.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i16.4191

Full Article (PDF)	WJG-22-4191.pdf
Full Article (Word)	WJG-22-4191.doc
Manuscript File	23511-Review.docx
Answering Reviewers	23511-Answering reviewers.pdf
Audio Core Tip	23511-Audio core tip.mp3
Biostatistics Review Certificate	23511-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23511-Conflict-of-interest statement.pdf
Copyright License Agreement	23511-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151202223329.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20151202223141.pdf
Peer-review Report	23511-Peer-review(s).pdf
Scientific Misconduct Check	23511-Scientific misconduct check.pdf
Scientific Editor Work List	23511-Scientific editor work list.pdf