Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	23521
Country	Japan

Received	2015-11-27 16:31
Peer-Review Started	2015-11-28 23:54
To Make the First Decision	2015-12-24 17:42
Return for Revision	2015-12-27 18:41
Revised	2016-01-20 16:14
Second Decision	2016-01-31 11:47
Accepted by Journal Editor-in-Chief	2016-02-03 08:26
Accepted by Executive Editor-in-Chief	2016-02-17 15:08
Articles in Press	2016-02-17 15:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-14 22:05
Publish the Manuscript Online	2016-04-20 23:11

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Immunology
Manuscript Type	Basic Study
Article Title	Oral tolerance is inducible during active dextran sulfate sodium-induced colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Satoshi Ino, Chikara Kohda, Kosuke Takeshima, Hiroki Ishikawa, Tomoko Norose, Toshiko Yamochi, Masafumi Takimoto, Hiroshi Takahashi and Kazuo Tanaka
Funding Agency and Grant Number
Corresponding Author	Chikara Kohda, PhD, Assistant Professor, Department of Microbiology and Immunology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. kohda@med.showa-u.ac.jp
Key Words	Cytokine; dextran sulfate sodium colitis; Oral tolerance; Regulatory T cell; Regulatory B cell
Core Tip	Our study is the first to demonstrate that oral tolerance is inducible during the active phase of dextran sulfate sodium (DSS)-induced colitis. Lymphocytic infiltration into the large intestine mucosa associated with epithelial defects did not influence oral tolerance. In DSS colitis, the frequencies of CD4+CD25+Foxp3+ T cells and B10 cells in the spleen and mesenteric lymph nodes remained stable. This stability might have led to the induction of oral tolerance in DSS colitis. Accordingly, if an appropriate antigen is chosen, then oral immunotherapy may be applicable for the treatment of ulcerative colitis.
Publish Date	2016-04-20 23:11
Citation	Ino S, Kohda C, Takeshima K, Ishikawa H, Norose T, Yamochi T, Takimoto M, Takahashi H, Tanaka K. Oral tolerance is inducible during active dextran sulfate sodium-induced colitis. World J Gastrointest Pharmacol Ther 2016; 7(2): 242-253
URL	http://www.wjgnet.com/2150-5349/full/v7/i2/242.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i2.242

Full Article (PDF)	WJGPT-7-242.pdf
Full Article (Word)	WJGPT-7-242.doc
Manuscript File	23521-Review.docx
Answering Reviewers	23521-Answering reviewrs.pdf
Audio Core Tip	23521-Audio core tip.mp3
Biostatistics Review Certificate	23521-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23521-Conflict-of-interest statement.pdf
Copyright License Agreement	23521-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	23521-Institutional animal care and use committee statement .pdf
Institutional Review Board Approval Form or Document	23521-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23521-Language certificate.pdf
Peer-review Report	23521-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23521-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23521-Scientific misconduct check.pdf
Scientific Editor Work List	23521-Scientific editor work list.pdf