Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	23536
Country	United Kingdom

Received	2015-11-29 13:05
Peer-Review Started	2015-11-30 13:58
To Make the First Decision	2015-12-28 12:14
Return for Revision	2015-12-28 16:36
Revised	2016-01-05 07:42
Second Decision	2016-01-25 14:49
Accepted by Journal Editor-in-Chief	2016-01-25 23:53
Accepted by Executive Editor-in-Chief	2016-02-16 09:59
Articles in Press	2016-02-16 09:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-21 10:23
Publish the Manuscript Online	2016-03-30 14:14

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Targeting inflammation in pancreatic cancer: Clinical translation
Manuscript Source	Invited Manuscript
All Author List	Colin William Steele, Nina Angharad Kaur Gill, Nigel Balfour Jamieson and Christopher Ross Carter
Funding Agency and Grant Number
Corresponding Author	Colin William Steele, MD, Department of Pancreaticobiliary Surgery, Glasgow Royal Infirmary, Queen Elizabeth Building, Glasgow G4 0SF, United Kingdom. cwsteele@hotmail.co.uk
Key Words	Pancreatic cancer; Inflammation; Stroma; Microenvironment
Core Tip	Many advances have been made in preclinical assessment of therapies in pancreatic cancer. Here we review the successes and failures of translation to clinical trial of therapies targeting the pancreatic cancer microenvironment. Using data from preclinical trials we expose opportunities for further clinical trial within pancreatic cancer. We focus on therapies that modulate the immune response to pancreatic cancer, stromally active therapies and therapies targeting inflammatory signal transduction that are key in pancreatic cancer progression. We provide experimental results that have led to clinical trial and those findings that may be exploited in future. We attempt to rationalize the failure of certain therapies to translate to clinical practice and provide a realistic overview of why at present tumor microenvironment targeted therapies are not licensed in pancreatic cancer.
Publish Date	2016-03-30 14:14
Citation	Steele CW, Kaur Gill NA, Jamieson NB, Carter CR. Targeting inflammation in pancreatic cancer: Clinical translation. World J Gastrointest Oncol 2016; 8(4): 380-388
URL	http://www.wjgnet.com/1948-5204/full/v8/i4/380.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i4.380

Full Article (PDF)	WJGO-8-380.pdf
Full Article (Word)	WJGO-8-380.doc
Manuscript File	23536-Review.docx
Answering Reviewers	23536-Answering reviewers.pdf
Audio Core Tip	23536-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23536-Conflict-of-interest statement.pdf
Copyright License Agreement	23536-Copyright assignment.pdf
Peer-review Report	23536-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23536-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23536-Scientific misconduct check.pdf
Scientific Editor Work List	23536-Scientific editor work list.pdf