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3/30/2016 2:15:00 PM | Browse: 812 | Download: 1096
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 23536
Country/Territory United Kingdom
2015-11-29 13:05
Peer-Review Started
2015-11-30 13:58
To Make the First Decision
2015-12-28 12:14
Return for Revision
2015-12-28 16:36
2016-01-05 07:42
Second Decision
2016-01-25 14:49
Accepted by Journal Editor-in-Chief
2016-01-25 23:53
Accepted by Company Editor-in-Chief
2016-02-16 09:59
Articles in Press
2016-02-16 09:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-03-21 10:23
Publish the Manuscript Online
2016-03-30 14:14
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Targeting inflammation in pancreatic cancer: Clinical translation
Manuscript Source Invited Manuscript
All Author List Colin William Steele, Nina Angharad Kaur Gill, Nigel Balfour Jamieson and Christopher Ross Carter
Funding Agency and Grant Number
Corresponding author Colin William Steele, MD, Department of Pancreaticobiliary Surgery, Glasgow Royal Infirmary, Queen Elizabeth Building, Glasgow G4 0SF, United Kingdom. cwsteele@hotmail.co.uk
Key Words Pancreatic cancer; Inflammation; Stroma; Microenvironment
Core Tip Many advances have been made in preclinical assessment of therapies in pancreatic cancer. Here we review the successes and failures of translation to clinical trial of therapies targeting the pancreatic cancer microenvironment. Using data from preclinical trials we expose opportunities for further clinical trial within pancreatic cancer. We focus on therapies that modulate the immune response to pancreatic cancer, stromally active therapies and therapies targeting inflammatory signal transduction that are key in pancreatic cancer progression. We provide experimental results that have led to clinical trial and those findings that may be exploited in future. We attempt to rationalize the failure of certain therapies to translate to clinical practice and provide a realistic overview of why at present tumor microenvironment targeted therapies are not licensed in pancreatic cancer.
Publish Date 2016-03-30 14:14
Citation Steele CW, Kaur Gill NA, Jamieson NB, Carter CR. Targeting inflammation in pancreatic cancer: Clinical translation. World J Gastrointest Oncol 2016; 8(4): 380-388
Url http://www.wjgnet.com/1948-5204/full/v8/i4/380.htm
DOI http://dx.doi.org/10.4251/wjgo.v8.i4.380
Full Article (PDF) WJGO-8-380.pdf
Full Article (Word) WJGO-8-380.doc
Manuscript File 23536-Review.docx
Answering Reviewers 23536-Answering reviewers.pdf
Audio Core Tip 23536-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 23536-Conflict-of-interest statement.pdf
Copyright License Agreement 23536-Copyright assignment.pdf
Peer-review Report 23536-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 23536-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 23536-Scientific misconduct check.pdf
Scientific Editor Work List 23536-Scientific editor work list.pdf