Publication Name	World Journal of Gastroenterology
Manuscript ID	23544
Country	China

Received	2015-11-30 08:04
Peer-Review Started	2015-11-30 08:09
First Decision by Editorial Office Director
Return for Revision	2015-12-16 15:02
Revised	2015-12-30 22:16
Publication Fee Transferred
Second Decision by Editor	2016-01-06 08:24
Second Decision by Editor-in-Chief	2016-01-08 14:20
Final Decision by Editorial Office Director	2016-01-18 10:49
Articles in Press	2016-01-18 10:49
Edit the Manuscript by Language Editor	2016-02-24 02:32
Typeset the Manuscript	2016-03-18 12:57
Publish the Manuscript Online	2016-04-03 18:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Norcantharidin combined with ABT-737 for hepatocellular carcinoma: Therapeutic effects and molecular mechanisms
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Ren, Gang Li, Wen Zhao, Ling Lin and Tao Ye
Funding Agency and Grant Number
Corresponding Author	Tao Ye, MD, Department of Oncology, Minhang Hospital, Fudan University, No. 170 Xinsong Road, Minhang District, Shanghai 201199, China. yaplter@vip.sina.com
Key Words	Norcantharidin; Hepatocellular carcinoma cell; Mcl-1
Core Tip	The effects of ABT-737 and norcantharidin (NCTD) alone or in combination on HepG2 and SMMC-7721 cells were tested by methyl thiazolyl tetra-zolium, Western blot and flow cytometry. We found that as the concentration of NCTD increased, the cell proliferation inhibition rate gradually decreased; and the treatment effect of ABT-737 1-3 μm combined with NCTD on cell proliferation inhibition was stronger than that of ABT-737 alone (p < 0.05). The effect on inducing apoptosis in HepG2 and SMMC-7721 cells with the treatment of ABT-737 combined with NCTD for 48 h was greater than that of ABT-737 or NCTD alone (p < 0.05). NCTD combined with ABT-737 has a positive role in the treatment of HCC.
Publish Date	2016-04-03 18:51
Citation	Ren J, Li G, Zhao W, Lin L, Ye T. Norcantharidin combined with ABT-737 for hepatocellular carcinoma: Therapeutic effects and molecular mechanisms. World J Gastroenterol 2016; 22(15): 3962-3968
URL	http://www.wjgnet.com/1007-9327/full/v22/i15/3962.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i15.3962

Full Article (PDF)	WJG-22-3962.pdf
Full Article (Word)	WJG-22-3962.doc
Manuscript File	23544-Review.doc
Answering Reviewers	23544-Answering reviewers.pdf
Audio Core Tip	23544-Audio core tip.m4a
Biostatistics Review Certificate	23544-Biostatistics statement.PDF
Conflict-of-Interest Disclosure Form	23544-Conflict-of-interest statement.PDF
Copyright License Agreement	23544-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	23544-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate	23544-Language certificate.pdf
Peer-review Report	23544-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23544-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23544-Scientific misconduct check.pdf
Scientific Editor Work List	23544-Scientific editor work list.pdf